Research project
 We have been invested the detail macrophage functions in various diseases using human samples and murine disease models. Since 1980s, so many research articles related to “macrophage” have been published from our laboratory. Our main techniques are immunostaining, PCR, Western blot, producing monoclonal antibody, gene construction, cell culture, microarray, and electron-microscopy. We are now focusing on following research.

1: The significance of tumor-associated macrophages (TAM) in human malignant tumors. Recently, many studies demonstrated that TAMs are closely involved in the development and progression of human malignant tumors. The in vivo and in vitro studies associated to malignant lymphoma, glioma, sarcoma, ovarian cancer, and kidney cancer are now under investigation.

2: The significant of macrophages in lymph node. Not only dendritic cells but also macrophages are involved in the immune system and lymphocyte activation in lymphoreticular systems. The correlation between anti-cancer immunity in cancer tissues and macrophages in lymph node are now under investigation.

3: Drug discovery and screening regulating macrophage functions. In various disorders such as cancer, metabolic syndrome, and atherosclerosis, macrophage activation is very important step in the pathological progression. Recently we reported the screening system of macrophage-regulating compounds and that corosolic acid significantly suppressed tumor development and lung metastasis. The studies using other novel compounds are now under investigation.

4: The functions of CD163 in macrophages. CD163 is a scavenger receptor specifically expressed on macrophage. CD163 is involved in the clearance of hemoglobin and haptoglobin complex and phagocytosis of bacteria. More detail functions or roles of CD163 are now under investigation using CD163-deficient mice.


Faculty of Life Sciences


Google Map
Graduate School of Medical Sciences

Accepted articles

Komohara Y.
Fujiwara Y.
Ohnishi K.

1. Yamashita K, Iwatsuki M, Harada K, Eto K, Hiyoshi Y, Ishimoto T, Nagai Y, Iwagami S, Miyamoto Y, Yoshida N, Komohara Y, Ajani JA, Baba H.
Prognostic impacts of the combined positive score and the tumor proportion score for programmed death ligand-1 expression by double immunohistochemical staining in patients with advanced gastric cancer.
Gastric Cancer 23: 95-104, 2020.

2. Urata K, Kajihara I, Miyauchi H, Mijiddorj T, Otsuka-Maeda S, Sakamoto R, Sawamura S, Kanemaru H, Kanazawa-Yamada S, Makino K, Aoi J, Makino T, Fukushima S, Komohara Y, Ihn H.
The Warburg effect and tumor immune microenvironment in extramammary Paget's disease: Overexpression of LDHA correlates with immune resistance.
J Eur Acad Dermatol Venereol, in press.

3. Terashima Y, Toda E, Itakura M, Otsuji M, Yoshinaga S, Okumura K, Shand FHW, Komohara Y, Takeda M, Kokubo K, Chen MC, Yokoi S, Rokutan H, Kofuku Y, Ohnishi K, Ohira M, Iizasa T, Nakano H, Okabe T, Kojima H, Shimizu A, Kanegasaki S, Zhang MR, Shimada I, Nagase H, Terasawa H, Matsushima K.
Targeting FROUNT with disulfiram suppresses macrophage accumulation and its tumor-promoting properties.
Nat Commun 11: 609, 2020.

4. Mito R, Matsubara E, Komohara Y, Shinchi Y, Sato K, Yoshii D, Ohnishi K, Fujiwara Y, Tomita Y, Ikeda K, Sakagami T, Suzuki M.
Clinical impact of TROP2 in non-small lung cancers and its correlation with abnormal p53 nuclear accumulation.
Pathol Int 70: 287-294, 2020.

5. Hide T, Komohara Y.
Oligodendrocyte Progenitor Cells in the Tumor Microenvironment.
Adv Exp Med Biol 1234:107-122, 2020.

6. Kim MW, Lee G, Niidome T, Komohara Y, Lee R, Park YI.
Platelet-Like Gold Nanostars for Cancer Therapy: The Ability to Treat Cancer and Evade Immune Reactions.
Front Bioeng Biotechnol 8: 133, 2020.

7. Okadome K, Baba Y, Nomoto D, Yagi T, Kalikawe R, Harada K, Hiyoshi Y, Nagai Y, Ishimoto T, Iwatsuki M, Iwagami S, Miyamoto Y, Yoshida N, Watanabe M, Komohara Y, Shono T, Sasaki Y, Baba H.
Prognostic and clinical impact of PD-L2 and PD-L1 expression in a cohort of 437 oesophageal cancers.
Br J Cancer 122: 1535-1543, 2020.

8. Pan C, Fujiwara Y, Horlad H, Shiraishi D, Iriki T, Tsuboki J, Ikeda T, Komohara Y.
Flavonoid Compounds Contained in Epimedii Herba Inhibit Tumor Progression by Suppressing STAT3 Activation in the Tumor Microenvironment.
Front Pharmacol 11:262, 2020.

9. Kaida T, Beppu T, Hayashi H, Imai K, Yamamura K, Okabe H, Matsumura K, Yoshii D, Komohara Y, Akahoshi S, Doi K, Yamashita YI, Baba H.
Inflammatory Liver Tumor Caused by Fasciola hepatica Mimicking Intrahepatic Cholangiocarcinoma.
Anticancer Res 40: 2795-2800, 2020.

10. Suzuki R, Fujiwara Y, Saito M, Arakawa S, Shirakawa JI, Yamanaka M, Komohara Y, Marumo K, Nagai R.
Intracellular Accumulation of Advanced Glycation End-Products Induces Osteoblast Apoptosis via Endoplasmic Reticulum Stress.
J Bone Miner Res, in press.

11. Yoshii D, Inomata Y, Komohara Y, Shimata K, Honda M, Hayashida S, Oya Y, Yamamoto H, Yamamoto H, Sugawara Y, Hibi T.
Ki67 Expression at Kasai Portoenterostomy as a Prognostic Factor in Patients With Biliary Atresia.
BJS Open, in press.

12. Yoshida M, Utsunomiya D, Takada S, Komohara Y, Mizoshiri T, Oda S, Harada K, Ikeda O.
The Imaging Findings of Peliosis Hepatis on Gadoxetic Acid Enhanced MRI.
Radiol Case Rep 15: 1261-1265, 2020.

13. Sawayama H, Komohara Y, Hirao H, Sakata K, Takata N, Yoshinaka I, Harada K, Baba H.
Nivolumab Exerts Therapeutic Effects Against Metastatic Lesions From Early Gastric Adenocarcinoma With a Small Proportion of Neuroendocrine Carcinoma After Gastrectomy: A Case Report.
Clin J Gastroenterol, in press.

14. Oda E, Beppu T, Kinoshita K, Yamamura K, Sato N, Yuki H, Chiyonaga S, Motohara T, Komohara Y, Akahoshi S.
Hepatic Xanthogranuloma That Originated From a Liver Cyst and Mimicked a Malignant Tumor.
In Vivo 34: 2067-2071, 2020.

15. Uchihara T, Miyake K, Yonemura A, Komohara Y, Itoyama R, Koiwa M, Yasuda T, Arima K, Harada K, Eto K, Hayashi H, Iwatsuki M, Iwagami S, Baba Y, Yoshida N, Yashiro M, Masuda M, Ajani JA, Tan P, Baba H, Ishimoto T.
Extracellular Vesicles From Cancer-Associated Fibroblasts Containing Annexin A6 Induces FAK-YAP Activation by Stabilizing β1 Integrin, Enhancing Drug Resistance.
Cancer Res, in press.

1. Komohara Y, Takeya H, Wakigami N, Kusada N, Bekki H, Ishihara S, Takeya M, Nakashima Y, Oda Y.
Positive correlation between the density of macrophages and T-cells in undifferentiated sarcoma.
Med Mol Morphol 52: 44-51, 2019.

2. Higuchi Y, Niidome T, Miyamoto Y, Komohara Y, Tokunou T, Kubota T, Horiuchi T.
Accumulation of gold nano-rods in the failing heart of transgenic mice with the cardiac-specific expression of TNF-α.
Heart Vessels 34: 538-544, 2019.

3. Yamamoto M, Motomura E, Yanagisawa, R, Hoang VAT, Mogi M, Mori T, Nakamura M, Takeya M, Eto K.
Evaluation of Neurobehavioral Impairment in Methylmercury-Treated KK-Ay Mice by Dynamic Weight- Bearing Test.
J Appl Toxicol 39: 221-230, 2019.

4. Tsukamoto M, Imai K, Ishimoto T, Komohara Y, Yamashita YI, Nakagawa S, Umezaki N, Yamao T, Kitano Y, Miyata T, Arima K, Okabe H, Baba Y, Chikamoto A, Ishiko T, Hirota M, Baba H.
PD-L1 expression enhancement by infiltrating macrophage-derived TNF-α leads to poor pancreatic cancer prognosis.
Cancer Sci 110; 310-320, 2019.

5. Maeda-Otsuka S, Kajihara I, Tasaki Y, Yamada-Kanazawa S, Sakamoto R, Sawamura S, Masuzawa M, Masuzawa M, Amoh Y, Hoshina D, Abe R, Komohara Y, Ihn H.
Hypoxia accelerates the progression of angiosarcoma through the regulation of angiosarcoma cells and tumor microenvironment.
J Dermatol Sci 93: 123-132, 2019.

6. Uto K, Sakamoto S, Que W, Shimata K, Hashimoto S, Sakisaka M, Narita Y, Yoshii D, Zhong L, Komohara Y, Li XK, Inomata Y, Hibi T.
Hydrogen-rich solution attenuates cold ischemia-reperfusion injury in rat liver transplantation.
BMC Gastroenterol 19: 25, 2019.

7. Hayashi K, Hasegawa Y, Takemoto Y, Cao C, Takeya H, Komohara Y, Mukasa A, Kim-Mitsuyama S.
Continuous intracerebroventricular injection of Porphyromonas gingivalis lipopolysaccharide induces systemic organ dysfunction in a mouse model of Alzheimer's disease.
Exp Gerontol 120: 1-5, 2019.

8. Yagi T, Baba Y, Okadome K, Kiyozumi Y, Hiyoshi Y, Ishimoto T, Iwatsuki M, Miyamoto Y, Yoshida N, Watanabe M, Komohara Y, Baba H.
Tumour-associated macrophages are associated with poor prognosis and programmed death ligand 1 expression in oesophageal cancer.
Eur J Cancer 111: 38-49, 2019.

9. Nakayama W, Fujiwara Y, Kosuge Y, Monthakantirat O, Fujikawa K, Watthana S, Susumu Kitanaka, Makino T, Ishiuchi K.
Phlenumdines D and E, new Lycopodium alkaloids from Phlegmariurus nummulariifolius, and their regulatory effects on macrophage differentiation during tumor development.
Phytochem Lett 29: 98-103, 2019.

10. Tanaka R, Saito Y, Fujiwara Y, Jo JI, Tabata Y.
Preparation of fibrin hydrogels to promote the recruitment of anti-inflammatory macrophages.
Acta Biomater 89:152-165, 2019.

11. Morimoto Y, Yoshida S, Kinoshita A, Satoh C, Mishima H, Yamaguchi N, Matsuda K, Sakaguchi M, Tanaka T, Komohara Y, Imamura A, Ozawa H, Nakashima M, Kurotaki N, Kishino T, Yoshiura KI, Ono S.
Nonsense mutation in CFAP43 causes normal-pressure hydrocephalus with ciliary abnormalities.
Neurology 92: e2364-e2374, 2019.

12. Kitano Y, Yamashita YI, Saito Y, Nakagawa S, Okabe H, Imai K, Komohara Y, Miyamoto Y, Chikamoto A, Ishiko T, Baba H.
Sarcopenia Affects Systemic and Local Immune System and Impacts Postoperative Outcome in Patients with Extrahepatic Cholangiocarcinoma.
World J Surg 43: 2271-2280, 2019.

13. Kiyozumi Y, Baba Y, Okadome K, Yagi T, Ishimoto T, Iwatsuki M, Miyamoto Y, Yoshida N, Watanabe M, Komohara Y, Baba H.
IDO1 Expression Is Associated With Immune Tolerance and Poor Prognosis in Patients With Surgically Resected Esophageal Cancer.
Ann Surg 269: 1101-1108, 2019.

Murakami-Nishida S, Matsumura T, Senokuchi T, Ishii N, Kinoshita H, Yamada S, Morita Y, Nishida S, Motoshima H, Kondo T, Komohara Y, Araki E.
Pioglitazone suppresses macrophage proliferation in apolipoprotein-E deficient mice by activating PPARγ..

Atherosclerosis 286: 30-39, 2019.

15. Yamashiro S, Uchikawa H, Yoshikawa M, Kuriwaki K, Hitoshi Y, Yoshida A, Komohara Y, Mukasa A.
Histological analysis of infiltrating macrophages in the cerebral aneur ysm walls.

J Clin Neurosci 67: 204-209, 2019.

16. Yamashita K, Iwatsuki M, Harada K, Koga Y, Kiyozumi Y, Eto K, Hiyoshi Y, Ishimoto T, Iwagami S, Baba Y, Miyamoto Y, Yoshida N, Komohara Y, Ajani JA, Baba H.
Can PD-L1 expression evaluated by biopsy sample accurately reflect its expression in the whole tumour in gastric cancer?
Br J Cancer 121: 278-280, 2019.

17. Shinchi Y, Komohara Y, Yonemitsu K, Sato K, Ohnishi K, Saito Y, Fujiwara, Y, Mori T, Shiraishi K, Ikeda K, Suzuki M.
Accurate expression of PD-L1/L2 in lung adenocarcinoma cells: a retrospective study by double immunohistochemistry.
Cancer sci 110: 2711-2721, 2019.

18. Yamashita T, Ohnishi K, Ueda M, Masuda T, Inoue Y, Misumi Y, Ueda A, Obayashi K, Takeya M, Ando Y.
Transthyretin amyloid-related cerebral angiitis after liver transplantation.
Amyloid 26(sup1): 11-12, 2019.

19. Umemoto S, Haruta M, Sakisaka M, Ikeda T, Tsukamoto H, Komohara Y, Takeya M, Nishimura Y, Senju S.
Cancer therapy with MHC-deficient and interferon β-producing myeloid cells derived from allogeneic embryonic stem cells.
Cancer Sci 110: 3027-3037, 2019.

20. Baba Y, Yagi T, Kosumi K, Okadome K, Nomoto D, Eto K, Hiyoshi Y, Nagai Y, Ishimoto T, Iwatsuki M, Iwagami S, Miyamoto Y, Yoshida N, Komohara Y, Watanabe M, Baba H.
Morphological lymphocytic reaction, patient prognosis and PD-1 expression after surgical resection for oesophageal cancer.
Br J Surg 106: 1352-1361, 2019.

21. Noyori O, Komohara Y, Nasser H, Hiyoshi M, Ma C, Pan C, Carreras J, Nakamura N, Sato A, Ando K, Okuno Y, Nosaka K, Matsuoka M, Suzu S.
Expression of IL-34 correlates with macrophage infiltration and prognosis of diffuse large B-cell lymphoma.
Clin Transl Immunology 8: e1074, 2019.

22. Takeya H, Ohnishi K, Shiota T, Saito Y, Fujiwara Y, Yagi T, Kiyozumi Y, Baba Y, Yoshida N, Asano K, Tanaka M, Baba H, Komohara Y.
Maf expression in human macrophages and lymph node sinus macrophages in patients with esophageal cancer.
J Clin Exp Hematop 59: 112-118, 2019.

23. Sato N, Beppu T, Kinoshita K, Yuki H, Suyama K, Chiyonaga S, Motohara T, Komohara Y, Hara A, Akahoshi S.
Conversion Hepatectomy for Huge Hepatocellular Carcinoma With Arterioportal Shunt After Chemoembolization and Lenvatinib Therapy.
Anticancer Res 39: 5695-5701, 2019.

24. Kinoshita S, Mera K, Ichikawa H, Shimasaki S, Nagai M, Taga Y, Iijima K, Hattori S, Fujiwara Y, Shirakawa JI, Nagai R.
Nω -(Carboxymethyl)arginine Is One of the Dominant Advanced Glycation End Products in Glycated Collagens and Mouse Tissues.
Oxid Med Cell Longev 2019: 9073451, 2019.

25. Nouno T, Okamoto M, Ohnishi K, Kaieda S, Tominaga M, Zaizen Y, Ichiki M, Momosaki S, Nakamura M, Fujimoto K, Fukuoka J, Shimizu S, Komohara Y, Hoshino T.
Elevation of pulmonary CD163+ and CD204+ macrophages is associated with the clinical course of idiopathic pulmonary fibrosis patients.
J Thorac Dis 11: 4005-4017, 2019.

26. Komohara Y, Harada M.
Potential mechanisms of spontaneous regression in patients with B-cell lymphoma; the significance of co-stimulatory molecules in lymphoma cells.
J Clin Exp Hematop 59: 207-210, 2019.

1. Ma C, Horlad H, Ohnishi K, Nakagawa T, Yamada S, Kitada S, Motoshima T, Kamba T, Nakayama T, Fujimoto N, Takeya M, Komohara Y.
CD163-positive cancer cells are potentially associated with high malignant potential in clear cell renal cell carcinoma.
Med Mol Morphol 51: 13-20, 2018.

2. Nohara T, Ono M, Nishioka N, Masuda F, Fujiwara Y, Ikeda T, Nakano D, Kinjo J.
New cyclic sulfides, garlicnins I2, M, N, and O, from Allium sativum.
J Nat Med 72: 326-331, 2018.

3. Kitano Y, Okabe H, Yamashita YI, Nakagawa S, Saito Y, Umezaki N, Tsukamoto M, Yamao T, Yamamura K, Arima K, Kaida T, Miyata T, Mima K, Imai K, Hashimoto D, Komohara Y, Chikamoto A, Ishiko T, Baba H.
Tumour-infiltrating inflammatory and immune cells in patients with extrahepatic cholangiocarcinoma.
Br J Cancer 118: 171-180, 2018.

4. Nohara T, Ono M, Nishioka N, Masuda F, Fujiwara Y, Ikeda T, Nakano D, Kinjo J.
New cyclic sulfides extracted from Allium sativum: garlicnins P, J2, and Q.
J Nat Med 72: 335-341, 2018.

5. Motoshima T, Miura Y, Wakigami N, Kusada N, Takano T, Inoshita N, Okaneya T, Sugiyama Y, Kamba T, Takeya M, Komohara Y.
Phenotypical change of tumor-associated macrophages in metastatic lesions of clear cell renal cell carcinoma.
Med Mol Morphol 51: 57-63, 2018.

6. Arima K, Komohara Y, Bu L, Tsukamoto M, Itoyama R, Miyake K, Uchihara T, Ogata Y, Nakagawa S, Okabe H, Imai K, Hashimoto D, Chikamoto A, Yamashita YI, Baba H, Ishimoto T.
Down-regulation of 15-PGDH by interleukin-1 beta from activated macrophages leads to poor prognosis in pancreatic cancer.
Cancer Sci 109: 462-470, 2018.

7. Omoto T, Kim-Kaneyama JR, Lei XF, Orimo A, Ohnishi K, Yoshihara K, Miyauchi A, Li S, Gao L, Umemoto T, Tanaka J, Nakahara K, Takeya M, Ishida F, Kudo SE, Haraguchi S, Miyazaki T, Miyazaki A.
The impact of stromal Hic-5 on the tumorigenesis of colorectal cancer through lysyl oxidase induction and stromal remodeling.
Oncogene 37: 1205-1219, 2018.

8. Yamada S, Senokuchi T, Matsumura T, Morita Y, Ishii N, Fukuda K, Murakami S, Nishida S, Kawasaki S, Motoshima H, Furukawa N, Komohara Y, Fujiwara Y, Koga T, Yamagata K, Takeya M, Araki E.
Inhibition of Local Macrophage Growth Ameliorates Focal Inflammation and Suppresses Atherosclerosis.
Arterioscler Thromb Vasc Biol 38: 994-1006, 2018.

9. Asano T, Ohnishi K, Shiota T, Motoshima T, Sugiyama Y, Yatsuda J, Kamba T, Ishizaka K, KomoharaY.
CD169-positive sinus macrophages in the lymph nodes determine bladder cancer prognosis.
Cancer Sci 106: 1723-1730, 2018.

10. Fujiwara Y, Saito Y, Shiota T, Cheng P, Ikeda T, Ohnishi K, Takeya M, Komohara Y.
Natural compounds that regulate lymph node sinus macrophages: Inducing an anti-tumor effect by regulating macrophage activation.
J Clin Exp Hematop 58: 17-23, 2018.

11. Hide T, Komohara Y, Miyasato Y, Nakamura H, Makino K, Takeya M, Kuratsu JI, Mukasa A, Yano S.
Oligodendrocyte Progenitor Cells and Macrophages/Microglia Produce Glioma Stem Cell Niches at the Tumor Border.
EBioMedicine 30: 94-104, 2018.

12. Shiraishi D, Fujiwara Y, Horlad H, Saito Y, Iriki T, Tsuboki J, Cheng P, Nakagata N, Mizuta H, Bekki H, Nakashima Y, Oda Y, Takeya M, Komohara Y.
CD163 is required for protumoral activation of macrophages in human and murine sarcoma.
Cancer Res 78: 3255-3266, 2018.

13. Miyasato Y, Yoshizawa T, Sato Y, Nakagawa T, Miyasato Y, Kakizoe Y, Kuwabara T, Adachi M, Ianni A, Braun T, Komohara Y, Mukoyama M, Yamagata K.
Sirtuin 7 Deficiency Ameliorates Cisplatin-induced Acute Kidney Injury Through Regulation of the Inflammatory Response.
Sci Rep 8: 5927, 2018.

14. Minayoshi Y, Maeda H, Yanagisawa H, Hamasaki K, Mizuta Y, Nishida K, Kinoshita R, Enoki Y, Imafuku T, Chuang VTG, Koga T, Fujiwara Y, Takeya M, Sonoda K, Wakayama T, Taguchi K, Ishima Y, Ishida T, Iwakiri Y, Tanaka M, Sasaki Y, Watanabe H, Otagiri M, Maruyama T.
Development of Kupffer cell targeting type-I interferon for the treatment of hepatitis via inducing anti-inflammatory and immunomodulatory actions.
Drug Deliv 25: 1067-1077, 2018.

15. Tanoue Y, Toyoda T, Sun J, Mustofa MK, Tateishi C, Endo S, Motoyama N, Araki K, Wu D, Okuno Y, Tsukamoto T, Takeya M, Ihn H, Vaziri C, Tateishi S.
Differential Roles of Rad18 and Chk2 in Genome Maintenance and Skin Carcinogenesis Following UV Exposure.
J Invest Dermatol 138: 2550-2557, 2018.

16. Miyasato Y, Takashima Y, Takeya H, Yano H, Hayano A, Nakagawa T, Makino K, Takeya M, Yamanaka R, Komohara Y.
The expression of PD-1 ligands and IDO1 by macrophages/microglia in primary central nervous system lymphoma.
J Clin Exp Hematop58: 95-101, 2018.

17. Imamura Y, Tashiro H, Tsend-Ayush G, Haruta M, Dashdemberel N, Komohara Y, Tsuboki J, Takaishi K, Ohba T, Nishimura Y, Katabuchi H, Senju S.
Novel therapeutic strategies for advanced ovarian cancer by using iPS cell-derived myelomonocytic cells producing interferon beta.
Cancer Sci 109: 3403-3410, 2018.

18. Endo S, Nishimura N, Kawano Y, Ueno N, Ueno S, Tatetsu H, Komohara Y, Takeya M, Hata H, Mitsuya H, Masao M, Okuno Y.
MUC1/KL-6 expression confers an aggressive phenotype upon myeloma cells.
Biochem Biophys Res Commun 507: 246-252, 2018.

19. Fujita A, Tsukaguchi H, Koshimizu E, Nakazato H, Itoh K, Kuraoka S, Komohara Y, Shiina M, Nakamura S, Kitajima M, Tsurusaki Y, Miyatake S, Ogata K, Iijima K, Matsumoto N, Miyake N.
Homozygous splicing mutation in NUP133 causes Galloway-Mowat syndrome.
Ann Neurol 84: 814-828, 2018.

20. Takamatsu K, Nakane S, Suzuki S, Kosaka T, Fukushima S, Kimura T, Miyashita A, Mukaino A, Yamakawa S, Watanabe K, Jinnin M, Komohara Y, Ihn H, Ando Y.
Immune checkpoint inhibitors in the onset of myasthenia gravis with hyperCKemia.
Ann Clin Transl Neurol 5: 1421-1427, 2018.

21. Takeya H, Shiota T, Yagi T, Ohnishi K, Baba Y, Miyasato Y, Kiyozumi Y, Yoshida N, Takeya M, Baba H, Komohara Y.
High CD169 expression in lymph node macrophages predicts a favorable clinical course in patients with esophageal cancer.
Pathol Int 68: 685-693, 2018.

22. Komohara Y, Noyori O, Saito Y, Takeya H, Baghdadi M, Kitagawa F, Hama N, Ishikawa K, Okuno Y, Nosaka K, Seino KI, Matsuoka M, Suzu S.
Potential anti-lymphoma effect of M-CSFR inhibitor in adult T-cell leukemia/lymphoma.
J Clin Exp Hematop 58: 152-160, 2018.

1. Komohara Y, Ohnishi K, Takeya M.
Possible functions of CD169-positive sinus macrophages in lymph nodes in anti-tumor immune responses.
Cancer Sci 108: 290-295, 2017.

2. Sakisaka M, Haruta M, Komohara Y, Umemoto S, Matsumura K, Ikeda T, Takeya M, Inomata Y, Nishimura Y, Senju S.
Therapy of primary and metastatic liver cancer by human iPS cell-derived myeloid cells producing interferon-β.
J Hepatobiliary Pancreat Sci 24: 109-119, 2017.

3.Ono M, Fujiwara Y, Ikeda T, Pan C, El-Aasr M, Lee JH, Nakano D, Kinjo J, Nohara T.
Atypical Cyclic Sulfides, Garlicnins G, I, and J, Extracted from Allium sativum.
Chem Pharm Bull (Tokyo) 65: 102-106, 2017.

4. Motoshima T, Komohara Y, Ma C, Dewi AK, Noguchi H, Yamada S, Nakayama T, Kitada S, Kawano Y, Takahashi W, Sugimoto M, Takeya M, Fujimoto N, Oda Y, Eto M.
PD-L1 expression in papillary renal cell carcinoma.
BMC Urol 17: 8, 2017.

5. Nohara T, Fujiwara Y, El-Aasr M, Ikeda T, Ono M, Nakano D, Kinjo J.
Antitumor Allium Sulfides.
Chem Pharm Bull (Tokyo) 65: 209-217, 2017.

6. Chikamoto A, Inoue R, Komohara Y, Sakamaki K, Hashimoto D, Shiraishi S, Takamori H, Yamashita YI, Yoshida N, Yamanaka T, Yamashita Y, Baba H.
Preoperative High Maximum Standardized Uptake Value in Association with Glucose Transporter 1 Predicts Poor Prognosis in Pancreatic Cancer.
Ann Surg Oncol 24: 2040-2047, 2017.

7. Komohara Y, Fujiwara Y, Ohnishi K, Horlad H, Saito Y, Takeya M.
Recent advances in research regarding to natural compounds that target pro-tumor macrophages.
Macrophage 4, 2017.

8. Iriki T, Ohnishi K, Fujiwara Y, Horlad H, Saito Y, Pan C, Ikeda K, Mori T, Suzuki M, Ichiyasu H, Kohrogi H, Takeya M, Komohara Y.
The cell-cell interaction between tumor-associated macrophages and small cell lung cancer cells is involved in tumor progression via STAT3 activation.
Lung Cancer 106: 22-32, 2017.

9. Nishimura N, Endo S, Ueno S, Ueno N, Tatetsu H, Hirata S, Hata H, Komohara Y, Takeya M, Mitsuya H, Okuno Y.
A xenograft model reveals that PU.1 functions as a tumor suppressor for multiple myeloma in vivo.
Biochem Biophys Res Commun 486: 916-922, 2017.

10. Komohara Y, Ma, C, Yano H, Pan C, Horlad H, Saito Y, Ohnishi K, Fujiwara Y, Okuno Y, Nosaka K, Shinosaki S, Morishita K, Matsuoka M, Wakayama T, Takeya M.
Cell adhesion molecule-1 (CADM1) expressed on adult T-cell leukemia/lymphoma cells is not involved in the interaction with macrophages.
J Clin Exp Hematop 57: 15-20, 2017.

11. Ma C, Horlad H, Pan C, Yano H, Ohnishi K, Fujiwara Y, Matsuoka M, Lee A, Niidome T, Yamanaka R, Takeya M, Komohara Y.
Stat3 inhibitor abrogates the expression of PD-1 ligands on lymphoma cell lines.
J Clin Exp Hematop 57: 21-25, 2017.

12. Miyasato Y, Shiota T, Ohnishi K, Pan C, Yano H, Horlad H, Yamamoto Y, Yamamoto-Ibusuki M, Iwase H, Takeya M, Komohara Y.
The high density of CD204-positive macrophages predicts worse clinical prognosis in patients with breast cancer.
Cancer Sci 108: 1693-1700, 2017

13. Yano H, Motoshima T, Ma C, Pan C, Yamada S, Nakayama T, Kitada S, Fujimoto N, Kamba T, Takeya M, Komohara Y.
The significance of TIMD4 expression in clear cell renal cell carcinoma.
Med Mol Morphol 50: 220-226, 2017.

14. Nakagawa T, Ohnishi K, Kosaki Y, Saito Y, Horlad H, Fujiwara Y, Takeya M, Komohara Y.
Optimum immunohistochemical procedures for analysis of macrophages in human and mouse formalin fixed paraffin-embedded tissue samples.
J Clin Exp Hematop 57: 31-36, 2017.

15. Iida Y, Harashima N, Motoshima T, Komohara Y, Eto M, Harada M.
Contrasting effects of cyclophosphamide on anti-CTLA-4 blockade therapy in two mouse tumor models.
Cance Sci 108: 1974-1984, 2017.

16. Komohara Y, Kawauchi R, Makiyama E, Mikami K, Horlad H, Fujiwara Y, Kida T, Takeya M, Niidome T.
Selective depletion of cultured macrophages by magnetite nanoparticles modified with gelatin.
Exp Ther Med 14:1640-1646, 2017.

17. Hayano A, Komohara Y, Takashima Y, Takeya H, Homma J, Fukai J, Iwadate Y, Kajiwara K, Ishizawa S, Hondoh H, Yamanaka R.
Programmed Cell Death Ligand 1 Expression in Primary Central Nervous System Lymphomas: A Clinicopathological Study.
Anticancer Res 37: 5655-5666, 2017.

18. Fukuda N, Noi K, Weng L, Kobashigawa Y, Miyazaki H, Wakeyama Y, Takaki M, Nakahara Y, Tatsuno Y, Uchida-Kamekura M, Suwa Y, Sato T, Ichikawa-Tomikawa N, Nomizu M, Fujiwara Y, Ohsaka F, Saitoh T, Maenaka K, Kumeta H, Shinya S, Kojima C, Ogura T, Morioka H.
Production of Single-Chain Fv Antibodies Specific for GA-Pyridine, an Advanced Glycation End-Product (AGE), with Reduced Inter-Domain Motion.
Molecules 22: E1695, 2017.

19. Hasegawa Y, Hayashi K, Takemoto Y, Cheng C, Takane K, Lin B, Komohara Y, Kim-Mitsuyama S.
DPP-4 inhibition with linagliptin ameliorates the progression of premature aging in klotho-/- mice.
Cardiovasc Diabetol 16: 154, 2017.

20. Itoh M, Suganami T, Kato H, Kanai S, Shirakawa I, Sakai T, Goto T, Asakawa M, Hidaka I, Sakugawa H, Ohnishi K, Komohara Y, Asano K, Sakaida I, Tanaka M, Ogawa Y.
CD11c+ resident macrophages drive hepatocyte death-triggered liver fibrosis in a murine model of nonalcoholic steatohepatitis.
JCI Insight 2: e92902, 2017.

Page Top

1. Fukuda R, Suico MA, Kai Y, Omachi K, Motomura K, Koga T, Komohara Y, Koyama K, Yokota T, Taura M, Shuto T, Kai H.
Podocyte p53 limits the severity of experimental Alport syndrome.
J Am Soc Nephrol 27: 144-157, 2016.

2. Komohara Y, Fujiwara Y, Ohnishi K, Shiraishi D, Takeya M.
Contribution of Macrophage Polarization to Metabolic Diseases.
J Atheroscler Thromb 23: 10-17, 2016.

3. Komohara Y, Fujiwara Y, Ohnishi K, Takeya M.
Tumor-associated macrophages: potential therapeutic targets for anti-cancer therapy. (review)
Adv Drug Deliv Rev 99: 180-185, 2016.

4. Nohara T, Fujiwara Y, Ikeda T, Murakami K, Ono M, El-Aasr M, Nakano D, Kinjo J.
Two new bicyclic sulfoxides from Welsh onion.
J Nat Med 70: 260-265, 2016.

5. Kuwahara K, Yamamoto-Ibusuki M, Zhang Z, Phimsen S, Gondo N, Yamashita H, Takeo T, Nakagata N, Yamashita D, Fukushima Y, Yamamoto Y, Iwata H, Saya H, Kondo E, Matsuo K, Takeya M, Iwase H, Sakaguchi N.
GANP protein encoded on human chromosome 21/mouse chromosome 10 is associated with resistance to mammary tumor development.
Cancer Sci 107: 469-477, 2016.

6. Nakashima K, Miyashita H, Yoshimitsu H, Fujiwara Y, Nagai R, Ikeda T.
Two new prenylflavonoids from Epimedii Herba and their inhibitory effects on advanced glycation end-products.
J Nat Med 70: 290-295, 2016.

7. Ma C, Komohara Y, Ohnishi K, Shimoji T, Kuwahara N, Sakumura Y, Matsuishi K, Fujiwara Y, Motoshima T, Takahashi W, Yamada S, Kitada S, Fujimoto N, Nakayama T, Eto M, Takeya M.
Infiltration of tumor-associated macrophages is involved in CD44 expression in clear cell renal cell carcinoma.
Cancer Sci 107: 700-707, 2016.

8. Ohnishi K, Yamaguchi M, Erdenebaatar C, Saito F, Tashiro H, Katabuchi H, Takeya M, Komohara Y.
Prognostic significance of CD169-positive lymph node sinus macrophages in patients with endometrial carcinoma.
Cancer Sci 107: 846-852, 2016.

9. Motoshima T, Komohara Y, Horlad H, Tsukamoto H, Fujita M, Saito Y, Tanoue K, Kasejima Y, Sugiyama Y, Kawano Y, Nishimura Y, Takeya M, Eto M.
CXCL10 and CCL2 mRNA expression in monocytes is inversely correlated with the HLA-DR lower fraction of monocytes in patients with renal cell carcinoma.
Oncol Lett 11: 1911-1916, 2016.

10. Yamanaka M, Matsumura T, Ohno R, Fujiwara Y, Shinagawa M, Sugawa H, Hatano K, Shirakawa J, Kinoshita H, Ito K, Sakata N, Araki E, Nagai R.
Non-invasive measurement of skin autofluorescence to evaluate diabetic complications.
J Clin Biochem Nutr 58: 135-140, 2016.

11. Arima K, Okabe H, Hashimoto D, Chikamoto A, Tsuji A, Yamamura K, Kitano Y, Inoue R, Kaida T, Higashi T, Taki K, Imai K, Komohara Y, Beppu T, Takeya M, Baba H.
The diagnostic role of the neutrophil-to-lymphocyte ratio in predicting pancreatic ductal adenocarcinoma in patients with pancreatic diseases.
Int J Clin Oncol, in press.

12. Ishiuchi K, Jiang WP, Fujiwara Y, Wu JB, Kitanaka S.
Serralongamines B-D, three new Lycopodium alkaloids from Lycopodium serratum var. longipetiolatum, and their inhibitory effects on foam cell formation in macrophages.
Bioorg Med Chem Lett 26: 2636-2640, 2016.

13. Fujiwara Y, Horlad H, Shiraishi D, Tsuboki J, Kudo R, Ikeda T, Nohara T, Takeya M, Komohara Y.
Onionin A, a sulfur-containing compound isolated from onions, impairs tumor development and lung metastasis by inhibiting the protumoral and immunosuppressive functions of myeloid cells.
Mol Nutr Food Res 60: 2467-2480, 2016.

14. Tsuboki J, Fujiwara Y, Horlad H, Shiraishi D, Nohara T, Tayama S, Motohara T, Saito Y, Ikeda T, Takaishi K, Tashiro H, Yonemoto Y, Katabuchi H, Takeya M, Komohara Y.
Onionin A inhibits ovarian cancer progression by suppressing cancer cell proliferation and the protumour function of macrophages.
Sci Rep 6: 29588, 2016.

15. Takeya M, Komohara Y.
Role of tumor-associated macrophages in human malignancies: friend or foe?
Pathol Int 66: 491-505, 2016.

16. Horlad H, Ohnishi K, Ma C, Fujiwara Y, Niino D, Ohshima K, Jinushi M, Matsuoka M, Takeya M, Komohara Y.
TIM-3 expression in lymphoma cells predicts chemoresistance in patients with adult T-cell leukemia/lymphoma (ATLL).
Oncol Lett 12: 1519-1524, 2016.

17. Miyazaki T, Tonami K, Hata S, Aiuchi T, Ohnishi K, Lei XF, Kim-Kaneyama JR, Takeya M, Itabe H, Sorimachi H, Kurihara H, Miyazaki A.
Calpain-6 confers atherogenicity to macrophages by dysregulating pre-mRNA splicing.
J Clin Invest 126: 3417-3432, 2016.

18. Sueta D, Sugamura K, Shimizu H, Shiota T, Yamamuro M, Hirakawa K, Sakamoto K, Tsujita K, Hanatani S, Yamamoto E, Araki S, Kanazawa H, Kojima S, Kaikita K, Hokimoto S, Komohara Y, Ogawa H.
A rare case of long-term survival with idiopathic dilatation of the pulmonary artery.
Int J Cardiol 223: 337-339, 2016.

19. Hasita H, Ma C, Yano H, Pan C, Ohnishi K, Fujiwara Y, Endo S, Kikukawa Y, Okuno Y, Matsuoka M, Takeya M, Komohara Y.
An IL-27/Stat3 axis induces expression of programmed cell death 1 ligands (PD-L1/2) on infiltrating macrophages in lymphoma.
Cancer Sci 107: 1696-1704, 2016.

20. Takaki M, Tanaka T, Komohara Y, Tsuchihashi Y, Mori D, Hayashi K, Fukuoka J, Yamasaki N, Nagayasu T, Ariyoshi K, Morimoto K, Nakata K.
Recurrence of pulmonary alveolar proteinosis after bilateral lung transplantation in a patient with a nonsense mutation in CSF2RB.
Respir Med Case Rep 19: 89-93, 2016.

21. Nitta H, Shimose T, Emi Y, Imamura T, Ohnishi K, Kusumoto T, Yamamoto M, Fukuzawa K, Takahashi I, Higashi H, Tsuji A, Akagi Y, Oki E, Maehara Y, Baba H; Kyushu Study Group of Clinical Cancer (KSCC) ancillary study.
Expression of the anaphylatoxin C5a receptor in gastric cancer: implications for vascular invasion and patient outcomes.
Med Oncol 33: 118, 2016.

22. Tian Z, Miyata K, Kadomatsu T, Horiguchi H, Fukushima H, Tohyama S, Ujihara Y, Okumura T, Yamaguchi S, Zhao J, Endo M, Morinaga J, Sato M, Sugizaki T, Zhu S, Terada K, Sakaguchi H, Komohara Y, Takeya M, Takeda N, Araki K, Manabe I, Fukuda K, Otsu K, Wada J, Murohara T, Mohri S, Yamashita JK, Sano M, Oike Y.
ANGPTL2 activity in cardiac pathologies accelerates heart failure by perturbing cardiac function and energy metabolism.
Nat Commun 7: 13016, 2016.

23. Wu Y, Wei FY, Kawarada L, Suzuki T, Araki K, Komohara Y, Fujimura A, Kaitsuka T, Takeya M, Oike Y, Suzuki T, Tomizawa K.
Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury.
PLoS Genet 12: e1006355, 2016.

24. Suenaga G, Ikeda T, Komohara Y, Takamatsu K, Kakuma T, Tasaki M, Misumi Y, Ueda M, Ito T, Senju S, Ando Y.
Involvement of Macrophages in the Pathogenesis of Familial Amyloid Polyneuropathy and Efficacy of Human iPS Cell-Derived Macrophages in Its Treatment.
PLoS One 11: e0163944, 2016.

25. Komohara Y, Takeya M.
CAFs and TAMs: Maestros of the tumour microenvironment.
J Pathol 240: 211-223, 2016.

26. Shiota T, Miyasato Y, Ohnishi K, Yamamoto-Ibusuki M, Yamamoto Y, Iwase H, Takeya M, Komohara Y.
The Clinical Significance of CD169-Positive Lymph Node Macrophage in Patients with Breast Cancer.
PLoS One 11: e0166680, 2016.

27. Fujiwara Y, Hizukuri Y, Yamashiro K, Makita N, Ohnishi K, Takeya M, Komohara Y, Hayashi Y.
Guanylate-binding protein 5 is a marker of interferon-γ- induced classically activated macrophages.
Clin Transl Immunology 5: e111, 2016

28. Komohara Y.
The role of tumor-associated microglia/macrophages in primary central nervous lymphoma: a new target for anti-lymphoma therapy?
Primary Central Nervous System Lymphoma (PCNSL): Incidence, Management and Outcomes.
Nova Science Publishers, Inc. p23-28, 2016.

Page Top

1. Ishimoto T, Izumi D, Watanabe M, Yoshida N, Hidaka K, Miyake K, Sugihara H, Sawayama H, Imamura Y, Iwatsuki M, Iwagami S, Baba Y, Horlad H, Komohara Y, Takeya M, Baba H.
Chronic inflammation with Helicobacter pylori infection is implicated in CD44 overexpression through miR-328 suppression in the gastric mucosa.
J Gastroenterol 50: 751-757, 2015.

2. Arita-Okubo S, Kim-Kaneyama JR, Lei XF, Fu WG, Ohnishi K, Takeya M, Miyauchi A, Honda H, Itabe H, Miyazaki T, Miyazaki A.
Role of Hic-5 in the formation of microvilli-like structures and the monocyte-endothelial interaction that accelerates atherosclerosis.
Cardiovasc Res 105: 361-371, 2015.

3. Jinushi M, Komohara Y.
Tumor-associated macrophages as an emerging target against tumors: Creating a new path from bench to bedside. [Review on Cancer]
Biochim Biophys Acta 1855: 124-130, 2015.

4. Komohara Y, Niino D, Ohnishi K, Ohshima K, Takeya M.
Role of tumor-associated macrophages in hematological malignancies. (Review)
Pathol Int 65: 170-176, 2015.

5. Nohara T, Fujiwara Y, Komota Y, Kondo Y, Saku T, Yamaguchi K, Komohara Y, Takeya M.
Cyclic Sulfoxides-Garlicnins K1, K2, and H1-Extracted from Allium sativum.
Chem Pharm Bull (Tokyo) 63: 117-121, 2015

6. Ohmoto T, Yoshitani N, Nishitsuji K, Takayama T, Yanagisawa Y, Takeya M, Sakashita N.
CD44-expressing undifferentiated carcinoma with rhabdoid features of the pancreas: Molecular analysis of aggressive invasion and metastasis.
Pathol Int 65: 264-270, 2015.

7. Takamoto H, Eguchi K, Kawabata T, Fujiwara Y, Takeya M, Tsukamoto S.
Inhibitors for cholesterol ester accumulation in macrophages from Chinese cabbage.
Biosci Biotechnol Biochem 79: 1315-1319, 2015.

8. Kosumi K, Baba Y, Ishimoto T, Harada K, Miyake K, Izumi D, Tokunaga R, Murata A, Eto K, Sugihara H, Shigaki H, Iwagami S, Sakamoto Y, Miyamoto Y, Yoshida N, Watanabe M, Komohara Y, Takeya M, Baba H.
Relationship between LINE-1 hypomethylation and Helicobacter pylori infection in gastric mucosae.
Med Oncol 32: 117, 2015.

9. Komohara Y, Morita T, Annan DA, Horlad H, Ohnishi K, Yamada S, Nakayama T, Kitada S, Suzu S, Kinoshita I, Dosaka-Akita H, Akashi K, Takeya M, Jinushi M.
The coordinated actions of TIM-3 on cancer and myeloid cells in the regulation of tumorigenicity and clinical prognosis in clear cell renal cell carcinomas.
Cancer Immunol Res 3: 999-1007, 2015.

10. Motoshima T, Komohara Y, Horlad H, Takeuchi A, Maeda Y, Tanoue K, Kawano Y, Harada M, Takeya M, Eto M.
Sorafenib enhances the anti-tumor effect of anti-CTLA-4 antibody by inhibiting myeloid-derived suppressor cells.
Oncol Rep 33: 2947-2953, 2015.

11. Enoki Y, Ishima Y, Tanaka R, Sato K, Kimachi K, Shirai T, Watanabe H, Chuang VT, Fujiwara Y, Takeya M, Otagiri M, Maruyama T.
Pleiotropic Effects of Levofloxacin, Fluoroquinolone Antibiotics, against Influenza Virus-Induced Lung Injury.
PLoS One 10: e0130248, 2015.

12. Saito Y, Ohnishi K, Miyashita A, Nakahara S, Fujiwara Y, Horlad H, Motoshima T, Fukushima S, Jinnin M, Ihn H, Takeya M, Komohara Y.
Prognostic significance of CD169+ lymph node sinus macrophages in patients with malignant melanoma.
Cancer Immunol Res 3: 1356-1363, 2015.

13. Eguchi K, Kato H, Fujiwara Y, Losung F, Mangindaan RE, de Voogd NJ, Takeya M, Tsukamoto S.
Bastadins, brominated-tyrosine derivatives, suppress accumulation of cholesterol ester in macrophages.
Bioorg Med Chem Lett 25: 5389-5392, 2015.

14. Nohara T, Fujiwara Y, Zhou JR, Urata J, Ikeda T, Murakami K, El-Aasr M, Ono M.
Saponins, Esculeosides B-1 and B-2, in Tomato Juice and Sapogenol, Esculeogenin B1.
Chem Pharm Bull (Tokyo) 63: 848-850, 2015.

15. Arima K, Okabe H, Hashimoto D, Chikamoto A, Kuroki H, Taki K, Kaida T, Higashi T, Nitta H, Komohara Y, Beppu T, Takeya M, Baba H.
The Neutrophil-to-Lymphocyte Ratio Predicts Malignant Potential in Intraductal Papillary Mucinous Neoplasms.
J Gastrointest Surg 19: 2171-2177, 2015.

16. Fujiwara Y, Shiraishi D, Yoshitomi M, Ikeda T, Mizuta H, Takeya M, Komohara Y.
Soyasapogenols contained in soybeans suppress tumour progression by regulating macrophage differentiation into the protumoural phenotype.
J Funct Foods 19: 594-605, 2015.

17. Oda E, Hashimoto D, Shiomi Y, Ohnishi K, Hayashi H, Chikamoto A, Takeya M, Baba H.
A case of occult intrahepatic cholangiocarcinoma diagnosed by autopsy.
Surg Case Rep 1: 101, 2015.

18. Sueta D, Sugamura K, Shimizu H, Shiota T, Yamamuro M, Hirakawa K, Sakamoto K, Tsujita K, Hanatani S, Yamamoto E, Araki S, Kanazawa H, Kojima S, Kaikita K, Hokimoto S, Komohara Y, Ogawa H.
A rare case of long-term survival with idiopathic dilatation of the pulmonary artery.
Int J Cardiol, in press.

Page Top

1. Komohara Y, Jinushi M, Takeya M.
Clinical significance of macrophage heterogeneity in human malignant tumors.
Cancer Sci 105: 1-8, 2014.

2. Kaku Y, Imaoka H, Morimatsu Y, Komohara Y, Ohnishi K, Oda H, Takenaka S, Matsuoka M, Kawayama T, Takeya M, Hoshino T.
Overexpression of CD163, CD204 and CD206 on alveolar macrophages in the lungs of patients with severe chronic obstructive pulmonary disease.
PLos One 9: e87400, 2014.

3. Noguchi H, Yamada S, Nabeshima A, Guo X, Tanimoto A, Wang KY, Kitada S, Tasaki T, Takama T, Shimajiri S, Horlad H, Komohara Y, Izumi H, Kohno K, Ichijo H, Sasaguri Y.
Depletion of apoptosis signal-regulating kinase 1 prevents bile duct ligation-induced necro-inflammation and subsequent peribiliary fibrosis.
Am J Pathol 184: 644-661, 2014.

4. Yamamoto M, Yanagisawa R, Motomura E, Nakamura M, Sakamoto M, Takeya M, Eto K.
Increased methylmercury toxicity related to obesity in diabetic KK-Ay mice.
J Appl Toxicol 34: 914-923, 2014.

5. Ishimoto T, Sugihara H, Watanabe M, Sawayama H, Iwatsuki M, Baba Y, Okabe H, Hidaka K, Yokoyama N, Miyake K, Yoshikawa M, Nagano O, Komohara Y, Takeya M, Saya H, Baba H.
Macrophage-derived reactive oxygen species suppress miR-328 targeting CD44 in cancer cells and promote redox adaptation.
Carcinogenesis 35: 1003-1011, 2014.

6. Horio E, Kadomatsu T, Miyata K, Arai Y, Hosokawa K, Doi Y, Ninomiya T, Horiguchi H, Endo M, Tabata M, Tazume H, Tian Z, Takahashi O, Terada K, Takeya M, Hao H, Hirose N, Minami T, Suda T, Kiyohara Y, Ogawa H, Kaikita K, Oike Y.
Role of Endothelial Cell-Derived Angptl2 in Vascular Inflammation Leading to Endothelial Dysfunction and Atherosclerosis Progression.
Arterioscler Thromb Vasc Biol 34: 790-800, 2014.

7. Yoshizawa T, Karim MF, Sato Y, Senokuchi T, Miyata K, Fukuda T, Go C, Tasaki M, Uchimura K, Kadomatsu T, Tian Z, Smolka C, Sawa T, Takeya M, Tomizawa K, Ando Y, Araki E, Akaike T, Braun T, Oike Y, Bober E, Yamagata K.
SIRT7 Controls Hepatic Lipid Metabolism by Regulating the Ubiquitin-Proteasome Pathway.
Cell Metab 19: 712-721, 2014.

8. Fujiwara Y, Takeya M, Komohara Y.
A Novel Strategy for Inducing the Antitumor Effects of Triterpenoid Compounds: Blocking the Protumoral Functions of Tumor-Associated Macrophages via STAT3 Inhibition.
Biomed Res Int 2014: 348539, 2014.

9. Khan S, Rahman HN, Okamoto T, Matsunaga T, Fujiwara Y, Sawa T, Yoshitake J, Ono K, Ahmed KA, Rahaman MM, Oyama K, Takeya M, Ida T, Kawamura Y, Fujii S, Akaike T.
Promotion of atherosclerosis by Helicobacter cinaedi infection that involves macrophage-driven proinflammatory responses.
Sci Rep 4: 4680, 2014.

10. Nohara T, Manabe H, Fujiwara Y, Ikeda T, Ono M, Murakami K, Nakano D, Kinjo J, Kajimoto T.
Conversion of tomato saponins to pregnane derivatives.
Chem Pharm Bull (Tokyo) 62: 483-487, 2014.

11. Nohara T, Fujiwara Y, Ikeda T, Yamaguchi K, Manabe H, Murakami K, Ono M, Nakano D, Kinjo J.
Acyclic Sulfides, Garlicnins L-1-L-4, E, and F, from Allium sativum.
Chem Pharm Bull (Tokyo) 62: 477-482, 2014.

12. El-Desoky AH, Kato H, Eguchi K, Kawabata T, Fujiwara Y, Losung F, Mangindaan RE, de Voogd NJ, Takeya M, Yokosawa H, Tsukamoto S.
Acantholactam and Pre-neo-kauluamine, Manzamine-Related Alkaloids from the Indonesian Marine Sponge Acanthostrongylophora ingens.
J Nat Prod 77: 1536-1540, 2014.

13. Saito Y, Komohara Y, Niino D, Horlad H, Ohnishi K, Takeya H, Kawaguchi H, Shimizu H, Ohshima K, Takeya M.
Role of CD204-positive tumor associated macrophages in adult T-cell leukemia/lymphoma.
J Clin Exp Hematop 54: 59-65, 2014.

14. Furusato A, Kato H, Nehira T, Eguchi K, Kawabata T, Fujiwara Y, Losung F, Mangindaan RE, de Voogd NJ, Takeya M, Yokosawa H, Tsukamoto S.
Acanthomanzamines A-E with New Manzamine Frameworks from the Marine Sponge Acanthostrongylophora ingens.
Org Lett 16: 3888-3891, 2014.

15. Ono M, Yasuda S, Komatsu H, Fujiwara Y, Takeya M, Nohara T.
Triterpenoids from the fruits and leaves of the blackberry (Rubus allegheniensis) and their inhibitory activities on foam cell formation in human monocyte-derived macrophage.
Nat Prod Res 28: 2347-2350, 2014.

16. Kobayashi D, Hirayama M, Komohara Y, Mizuguchi S, Wilson Morifuji M, Ihn H, Takeya M, Kuramochi A, Araki N.
Translationally Controlled Tumor Protein is a Novel Biological Target for Neurofibromatosis Type 1 (NF1)-associated Tumors.
J Biol Chem 289: 26314-26326, 2014.

17. Nagai R, Shirakawa J, Fujiwara Y, Ohno R, Moroishi N, Sakata N, Nagai M.
Detection of AGEs as markers for carbohydrate metabolism and protein denaturation.
J Clin Biochem Nutr 55: 1-6, 2014.

18. Yamashita S, Sakashita N, Yamashita T, Tawara N, Tasaki M, Kawakami K, Komohara Y, Fujiwara Y, Kamikawa M, Nakagawa T, Hirano T, Maeda Y, Hasegawa M, Takeya M, Ando Y.
Concomitant accumulation of α-synuclein and TDP-43 in a patient with corticobasal degeneration.
J Neurol 261, 2209-2217, 2014.

19. Kamikawa M, Lei X, Fujiwara Y, Nishitsuji K, Mizuta H, Takeya M, Sakashita N.
ACAT1-associated Late Endosomes/Lysosomes Significantly Improve Impaired Intracellular Cholesterol Metabolism and the Survival of Niemann-Pick Type C Mice.
Acta Histochem Cytochem 47: 35-43, 2014.

20. Nohara T, Fujiwara Y, Kudo R, Yamaguchi K, Ikeda T, Murakami K, Ono M, Kajimoto T, Takeya M.
Isolation and Characterization of New Onionins A2 and A3 from Allium cepa, and of Onionins A1, A2, and A3 from Allium fistulosum.
Chem Pharm Bull (Tokyo) 62: 1141-1145, 2014.

Page Top

1. Yuki H, Ueno S, Tatetsu H, Niiro H, Iino T, Endo S, Kawano Y, Komohara Y, Takeya M, Hata H, Okada S, Watanabe T, Akashi K, Mitsuya H, Okuno Y.
PU.1 is a potent tumor suppressor in classical Hodgkin lymphoma cells.
Blood 121: 962-970, 2013.

2. Kinoshita H, Matsumura T, Ishii N, Fukuda K, Senokuchi T, Motoshima H, Kondo T, Taketa K, Kawasaki S, Hanatani S, Takeya M, Nishikawa T, Araki E.
Apocynin suppresses the progression of atherosclerosis in apoE-deficient mice by inactivation of macrophages.
Biochem Biophys Res Commun 431: 124-130, 2013.

3. Tian Z, Miyata K, Tazume H, Sakauguchi H, Kadomatsu T, Horio E, Takahashi O, Komohara Y, Araki K, Hirata Y, Tabata M, Takanashi S, Takeya M, Hao H, Shimabukuro M, Sata M, Kawasuji M, Oike Y.
Perivascular adipose tissue-secreted angiopoietin-like protein2 (Angptl2) accelerates neointimal hyperplasia after endovascular injury.
J Mol Cell Cardiol 57: 1-12, 2013.

4. Yeung JT, Hamilton RL, Ohnishi K, Ikeura M, Potter DM, Nikiforova MN, Ferrone S, Jakacki RI, Pollack IF, Okada H.
LOH in the HLA Class I region at 6p21 is Associated with Shorter Survival in Newly Diagnosed Adult Glioblastoma.
Clin Cancer Res 19: 1816-1826, 2013.

5. Horlad H, Fujiwara Y, Takemura K, Ohnishi K, Ikeda T, Tsukamoto H, Mizuta H, Nishimura Y, Takeya M, Komohara Y.
Corosolic acid impairs tumor development and lung metastasis by inhibiting the immunosuppressive activity of myeloid-derived suppressor cells.
Mol Nutr Food Res 57: 1046-1054, 2013.

6. Itoh F, Komohara Y, Takaishi K, Honda R, Tashiro H, Kyo S, Katabuchi H, Takeya M.
Possible involvement of Stat3 in cell-cell interaction between peritoneal macrophages and endometrial stromal cells in human endometriosis.
Fertil Steril 99: 1705-1713, 2013.

7. Komohara Y, Niino D, Saito Y, Ohnishi K, Hasita H, Ohshima K, Takeya M.
Clinical significance of CD163+ tumor-associated macrophages in patients with adult T-cell leukemia/lymphoma.
Cancer Sci 104: 945-951, 2013.

8. Hara A, Sakai N, Furuichi K, Sakai Y, Takeya M, Bucala R, Mukaida N, Takuwa Y, Matsushima K, Kaneko S, Wada T.
CCL2/CCR2 augments the production of transforming growth factor-beta1, type 1 collagen and CCL2 by human CD45-/collagen 1-positive cells under high glucose concentrations.
Clin Exp Nephrol 17: 793-804, 2013.

9. Nakagawa T, Sakashita N, Ohnishi K, Komohara Y, Takeya M.
Imprint cytological feature of large cell neuroendocrine carcinoma of the gallbladder: A case report.
J Med Invest 60: 149-153, 2013.

10. Eguchi K, Fujiwara Y, Hayashida A, Horlad H, Kato H, Rotinsulu H, Losung F, Mangindaan RE, de Voogd NJ, Takeya M, Tsukamoto S.
Manzamine A, a marine-derived alkaloid, inhibits accumulation of cholesterol ester in macrophages and suppresses hyperlipidemia and atherosclerosis in vivo.
Bioorg Med Chem 21: 3831-3838, 2013.

11. Niibori-Nambu A, Midorikawa U, Mizuguchi S, Hide T, Nagai M, Komohara Y, Nagayama M, Hirayama M, Kobayashi D, Tsubota N, Takezaki T, Makino K, Nakamura H, Takeya M, Kuratsu J, Araki N.
Glioma Initiating Cells Form a Differentiation Niche Via the Induction of Extracellular Matrices and Integrin αV.
PLoS One 8: e59558, 2013.

12. Sakashita N, Kagawa S, Date S, Ueno T, Nakagawa T, Yamashita T, Obayashi K, Ohshima T, Ueda M, Horiguchi H, Ando Y, Takeya M.
Marked cardiomegaly in a patient with familial amyloidotic polyneuropathy after orthotopic liver transplantation: a case study.
Pathol Int 63: 260-265, 2013.

13. Nohara T, Fujiwara Y, Ikeda T, Murakami K, Ono M, Nakano D, Kinjo J.
Cyclic Sulfoxides Garlicnins B2, B3, B4, C2, and C3 from Allium sativum.
Chem Pharm Bull (Tokyo) 61: 695-699, 2013.

14. Manabe H, Fujiwara Y, Ikeda T, Ono M, Murakami K, Zhou JR, Yokomizo K, Nohara T.
Saponins esculeosides B-1 and B-2 in italian canned tomatoes.
Chem Pharm Bull (Tokyo) 61: 764-767, 2013.

15. Ohnishi K, Komohara Y, Saito Y, Miyamoto Y, Watanabe M, Baba H, Takeya M.
CD169-positive macrophages in regional lymph nodes are associated with a favorable prognosis in patients with colorectal carcinoma.
Cancer Sci 104: 1237-1244, 2013.

16. Bai B, Horlad H, Saito Y, Ohnishi K, Fujiwara Y, Takeya M, Komohara Y.
Role of Stat3 activation in cell-cell interaction between B-cell lymphoma and macrophages: the in vitro study.
J Clin Exp Hematop 53: 127-133, 2013.

17. Fujiwara Y, Takaishi K, Nakao J, Ikeda T, Katabuchi H, Takeya M, Komohara Y.
Corosolic acid enhances the anti-tumor effects of chemotherapy to ovarian cancer by inhibiting STAT3 signaling.
Oncol Lett 6: 1619-1623, 2013.

18. Sugihara H, Ishimoto T, Watanabe M, Sawayama H, Iwatsuki M, Baba Y, Komohara Y, Takeya M, Baba H.
Identification of miR-30e* regulation of Bmi1 expression mediated by tumor-associated macrophages in gastrointestinal cancer.
PLos One 8: e81839, 2013.

19. Itoh M, Kato H, Suganami T, Konuma K, Marumoto Y, Terai S, Sakugawa H, Kanai A, Hamaguchi M, Fukaishi T, Aoe S, Akiyoshi K, Komohara Y, Takeya M, Sakaida I, Ogawa Y.
Hepatic crown-like structure: a unique histological feature in non-alcoholic steatohepatitis in mice and humans.
PLos One 8: e82163, 2013.

20. Baghdadi M, Yoneda A, Yamashina T, Nagao H, Komohara Y, Nagai S, Akiba H, Foretz M, Yoshiyama H, Kinoshita I, Dosaka-Akita H, Takeya M, Viollet B, Yagita H, Jinushi M.
TIM-4 Glycoprotein-Mediated Degradation of Dying Tumor Cells by Autophagy Leads to Reduced Antigen Presentation and Increased Immune Tolerance.
Immunity 39: 1070-1081, 2013.

Page Top

1. Morimatsu Y, Sakashita N, Komohara Y, Ohnishi K, Masuda H, Dahan D, Takeya M, Guibert C, Marthan R.
Development and Characterization of an Animal Model of Severe Pulmonary Arterial Hypertension.
J Vasc Res 49: 33-42, 2012.

2. Kobayashi C, Shiina T, Tokioka A, Hattori Y, Komori T, Kobayashi-Miura M, Takizawa T, Takahara K, Inaba K, Inoko H, Takeya M, Dranoff G, Sugita M.
GM-CSF-Independent CD1a Expression in Epidermal Langerhans Cells: Evidence from Human CD1A Genome-Transgenic Mice.
J Invest Dermatol 132: 241-244, 2012.

3. Kawaguchi A, Yajima N, Komohara Y, Aoki H, Tsuchiya N, Homma J, Sano M, Natsumeda M, Uzuka T, Saitoh A, Takahashi H, Sakai Y, Takahashi H, Fujii Y, Kakuma T, Yamanaka R.
Identification and validation of gene expression signature that predicts outcome in malignant glioma patients.
Int J Oncol 40: 721-730, 2012.

4. Matsubara J, Sugamura K, Nakamura T, Fujiwara Y, Akiyama E, Kurokawa H, Nozaki T, Ohba K, Konishi M, Maeda H, Izumiya Y, Kaikita K, Sumida H, Jinnouchi H, Matsui K, Kim-Mitsuyama S, Takeya M, Ogawa H.
Dipeptidyl Peptidase-4 Inhibitor, Des-Fluoro-Sitagliptin, Improves Endothelial Function and Reduces Atherosclerotic Lesion Formation in Apolipoprotein-E Deficient Mice.
J Am Coll Cardiol 59: 265-276, 2012.

5. Fujiwara Y, Kiyota N, Tsurushima K, Yoshitomi M, Horlad H, Ikeda T, Nohara T, Takeya M, Nagai R.
Tomatidine, a Tomato Sapogenol, Ameliorates Hyperlipidemia and Atherosclerosis in ApoE-Deficient Mice by Inhibiting Acyl-CoA:cholesterol Acyl-transferase (ACAT).
J Agric Food Chem 60, 2472-2479, 2012.

6. Khan S, Okamoto T, Enomoto K, Sakashita N, Oyama K, Fujii S, Sawa T, Takeya M, Ogawa H, Yamabe H, Akaike T.
Potential association of Helicobacter cinaedi with atrial arrhythmia and atherosclerosis.
Microbiol Immunol 56: 145-154, 2012.

7. Liu Y, Komohara Y, Domenick N, Ohno M, Ikeura M, Hamilton RL, Horbinski C, Wang X, Ferrone S, Okada H.
Expression of antigen processing and presenting molecules in brain metastasis of breast cancer.
Cancer Immunol Immunother 61: 789-801, 2012.

8. Miyamoto H, Suzuki T, Miyauchi Y, Iwasaki R, Kobayashi T, Sato Y, Miyamoto K, Hoshi H, Hashimoto K, Yoshida S, Hao W, Mori T, Kanagawa H, Katsuyama E, Fujie A, Morioka H, Matsumoto M, Chiba K, Takeya M, Toyama Y, Miyamoto T.
OC-STAMP and DC-STAMP cooperatively modulate cell-cell fusion to form osteoclasts and foreign body giant cells.
J Bone Miner Res 27: 1289-1297, 2012.

9. Nohara T, Kiyota Y, Sakamoto T, Manabe H, Ono M, Ikeda T, Fujiwara Y, Nakano D, Kinjo J.
Garlicnins B1, C1, and D, from the Fraction Regulating Macrophage Activation of Allium sativum.
Chem Pharm Bull (Tokyo) 60: 747-51, 2012.

10. Fang J, Greish K, Qin H, Liao L, Nakamura H, Takeya M, Maeda H.
HSP32 (HO-1) inhibitor, zinc protoporphyrin IX, a water-soluble micelle of copoly(styrene-maleic acid) as anticancer agent: In vitro and in vivo anticancer effect.
Eur J Pharm Biopharm 81: 540-547, 2012.

11. Hayashi H, Eguchi Y, Fukuchi-Nakaishi Y, Takeya M, Nakagata N, Tanaka K, Vance JE, Tanihara H.
A potential neuroprotective role of apolipoprotein E-containing lipoproteins through low density lipoprotein receptor-related protein 1 in normal tension glaucoma.
J Biol Chem 287: 25395-25406, 2012.

12. Yamamoto M, Takeya M, Ikeshima-Kataoka H, Yasui M, Kawasaki Y, Shiraishi M, Majima E, Shiraishi S, Uezono Y, Sasaki M, Eto K.
Increased expression of aquaporin-4 by methylmercury in the brain of Common Marmoset.
J Toxicol Sci 37: 749-763, 2012.

13. Shiraishi D, Fujiwara Y, Komohara Y, Mizuta H, Takeya M.
Gulucagon-like peptide-1(GLP-1) induces M2 polarization of human macrophages via STAT3 activation.
BIochem BIophys Res Commun 425: 304-308, 2012.

14. Lai YL, Aoyama S, Ohata M, Otsuka N, Shiokawa H, Tomono S, Fujiwara Y, Kanazawa H, Miyoshi N, Ohshima H.
Dysregulation of dimethylarginine dimethylaminohydrolase/asymmetric dimethylarginine pathway in rat type II diabetic nephropathy.
J Clin Biochem Nutr 51: 143-149, 2012.

15. Kawaguchi A, Iwadate Y, Komohara Y, Sano M, Kajiwara K, Yajima N, Tsuchiya N, Homma J, Aoki H, Kobayashi T, Sakai Y, Hondoh H, Fujii Y, Kakuma T, Yamanaka R.
Gene Expression Signature-Based Prognostic Risk Score in Primary Central Nervous System Lymphoma Patients.
Clin Cancer Res 18: 5672-5681, 2012.

16. Komohara Y, Hasita H, Ohnishi K, Fujiwara Y, Bai B, Nakagawa T, Suzu S, Nakamura H, Kuratsu J, Takeya M.
Importance of direct macrophage-tumor cell interaction on progression of human glioma.
Cancer Science 103: 2165-2172, 2012.

17. Ohnishi K, Oghiso Y, Takeya M.
Immunohistochemical Detection of a Possible Cellular Origin of Hepatic Histiocytic Sarcoma in Mice.
J Clin Exp Hematop 52: 171-177, 2012.

Page Top

1. Fujiwara Y, Komohara Y, Ikeda T, Takeya M.
Corosolic acid inhibits glioblastoma cell proliferation by suppressing the activation of signal transducer and activator of transcription-3 and nuclear factor-kappa B in tumor cells and tumor-associated macrophages.
Cancer Sci 102: 206-211, 2011.

2. Manabe H, Murakami Y, El-Aasr M, Ikeda T, Fujiwara Y, Ono M, Nohara T.
Content variations of the tomato saponin esculeoside A in various processed tomatoes.
J Nat Med 65: 176-179, 2011.

3. Fujiwara Y, Kiyota N, Tsurushima K, Yoshitomi M, Mera K, Sakashita N, Takeya M, Ikeda T, Araki T, Nohara T, Nagai R.
Natural Compounds Containing a Catechol Group Enhance the Formation of N<epsilon>-(carboxymethyl)lysine of the Maillard Reaction.
Free Radic Biol Med 50: 883-891, 2011.

4. Hashimoto Y, Shuto T, Mizunoe S, Tomita A, Koga T, Sato T, Takeya M, Suico MA, Niibori A, Sugahara T, Shimasaki S, Sugiyama T, Scholte B, Kai H.
CFTR-deficiency renders mice highly susceptible to cutaneous symptoms during mite infestation.
Lab Invest 91: 509-518, 2011.

5. Fujita M, Kohanbash G, Fellows-Mayle W, Hamilton RL, Komohara Y, Decker SA, Ohlfest JR, Okada H.
COX-2 blockade suppresses gliomagenesis by inhibiting myeloid-derived suppressor cells.
Cancer Res 71: 2664-2674, 2011.

6. Sakashita N, Motooka Y, Suganuma M, Ohnishi K, Fujiwara Y, Nakagawa T, Ichiyasu H, Takeya M.
A case of pulmonary capillary hemangiomatosis with pulmonary fibrosis associated with MMP-9 related pulmonary remodeling.
Pathol Int 61: 306-312, 2011.

7. Katsumata A, Kimura M, Saigo H, Aburaya K, Nakano M, Ikeda T, Fujiwara Y, Nagai R.
Changes in Esculeoside A Content in Different Regions of the Tomato Fruit during Maturation and Heat Processing.
J Agric Food Chem 59: 4104-4110, 2011.

8. Fujiwara Y, Hayashida A, Tsurushima K, Nagai R, Yoshitomi M, Daiguji N, Sakashita N, Takeya M, Tsukamoto S, Ikeda T.
Triterpenoids Isolated from Zizyphus jujuba Inhibit Foam Cell Formation in Macrophages.
J Agric Food Chem 59: 4544-4552, 2011.

9. Komohara Y, Hasita H, Ohnishi K, Fujiwara Y, Suzu S, Eto M, Takeya M.
Macrophage infiltration and its prognostic relevance in clear renal cell carcinoma.
Cancer Sci 102: 1424-1431, 2011.

10. Ohnishi K, Komohara Y, Fujiwara Y, Takemura K, Lei X, Nakagawa T, Sakashita N, Takeya M.
Suppression of TLR4-mediated inflammatory response by macrophage class A scavenger receptor (CD204).
Biochem Biophys Res Commun 411: 516-522, 2011.

11. Fujiwara Y, Komohara Y, Kudo R, Tsurushima K, Ohnishi K, Ikeda T, Takeya M.
Oleanolic acid inhibits macrophage differentiation into the M2 phenotype and glioblastoma cell proliferation by suppressing the activation of STAT3.
Oncol Rep 26: 1533-1537, 2011.

12. El-Aasr M, Fujiwara Y, Takeya M, Ono M, Nakano D, Okawa M, Kinjo J, Ikeda T, Miyashita H, Yoshimitsu H, Nohara T.
Garlicnin A from the Fraction Regulating Macrophage Activation of Allium sativum.
Chem Pharm Bull (Tokyo) 59: 1340-1343, 2011.

13. Komohara Y, Horlad H, Ohnishi K, Ohta K, Makino K, Hondo H, Yamanaka R, Kajiwara K, Saito T, Kuratsu J, Takeya M.
M2 macrophage/microglial cells induce activation of Stat3 in primary central nervous system lymphoma.
J Clin Exp Hematop 51: 93-99, 2011.

14. Shimasaki S, Kubota M, Yoshitomi M, Takagi K, Suda K, Mera K, Fujiwara Y, Nagai R.
Nw-(carboxymethyl)arginine Accumulates in Glycated Collagen and Klotho-deficient Mouse Skin.
Anti-Asing Medicine 8: 82-87, 2011.

Page Top

Page Top