Research project
 We have been invested the detail macrophage functions in various diseases using human samples and murine disease models. Since 1980s, so many research articles related to “macrophage” have been published from our laboratory. Our main techniques are immunostaining, PCR, Western blot, producing monoclonal antibody, gene construction, cell culture, microarray, and electron-microscopy. We are now focusing on following research.

1: The significance of tumor-associated macrophages (TAM) in human malignant tumors. Recently, many studies demonstrated that TAMs are closely involved in the development and progression of human malignant tumors. The in vivo and in vitro studies associated to malignant lymphoma, glioma, sarcoma, ovarian cancer, and kidney cancer are now under investigation.

2: The significant of macrophages in lymph node. Not only dendritic cells but also macrophages are involved in the immune system and lymphocyte activation in lymphoreticular systems. The correlation between anti-cancer immunity in cancer tissues and macrophages in lymph node are now under investigation.

3: Drug discovery and screening regulating macrophage functions. In various disorders such as cancer, metabolic syndrome, and atherosclerosis, macrophage activation is very important step in the pathological progression. Recently we reported the screening system of macrophage-regulating compounds and that corosolic acid significantly suppressed tumor development and lung metastasis. The studies using other novel compounds are now under investigation.

4: The functions of CD163 in macrophages. CD163 is a scavenger receptor specifically expressed on macrophage. CD163 is involved in the clearance of hemoglobin and haptoglobin complex and phagocytosis of bacteria. More detail functions or roles of CD163 are now under investigation using CD163-deficient mice.


Members

Faculty of Life Sciences


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Graduate School of Medical Sciences


Accepted articles

Komohara Y.
Fujiwara Y.


2021
1.Yoshii D, Nakagawa T, Komohara Y, Kawaguchi H, Yamada S, Tanimoto A.
Phenotypic Changes in Macrophage Activation in a Model of Nonalcoholic Fatty Liver Disease using Microminipigs.
J Atheroscler Thromb 28: 444-451, 2021.

2.Saku T, Takashio S, Tsuruta Y, Otsuka Y, Takae M, Kiyama T, Yamamoto E, Kaikita K, Hotta T, Matsumoto S, Kang D, Tsujita K, Komohara Y.
Comparison of electron microscopic findings and clinical presentation in three patients with mitochondrial cardiomyopathy caused by the mitochondrial DNA mutation m.3243A > G.
Med Mol Morphol 54: 181-186, 2021.

3.Kanemitsu K, Iwatsuki M, Yamashita K, Komohara Y, Morinaga T, Iwagami S, Eto K, Nagai Y, Kurashige J, Baba Y, Yoshida N, Baba H.
Two Asian families with gastric adenocarcinoma and proximal polyposis of the stomach successfully treated via laparoscopic total gastrectomy.
Clin J Gastroenterol 14: 92-97, 2021.

4.Liu Y, Baba Y, Ishimoto T, Tsutsuki H, Zhang T, Nomoto D, Okadome K, Yamamura K, Harada K, Eto K, Hiyoshi Y, Iwatsuki M, Nagai Y, Iwagami S, Miyamoto Y, Yoshida N, Komohara Y, Ohmuraya M, Wang X, Ajani JA, Sawa T, Baba H.
Fusobacterium nucleatum confers chemoresistance by modulating autophagy in oesophageal squamous cell carcinoma.
Br J Cancer 124: 963-974, 2021.

5. Kusunoki M, Fujiwara Y, Komohara Y, Imamura Y, Honda R, Ohba T, Katabuchi H.
Hemoglobin-induced continuous activation of macrophages in endometriotic cysts: a potential mechanism of endometriosis development and carcinogenesis.
Med Mol Morphol 54: 122-132, 2021.

6. Nomoto D, Baba Y, Okadome K, Yagi T, Kalikawe R, Kiyozumi Y, Harada K, Eto K, Hiyoshi Y, Nagai Y, Ishimoto T, Iwatsuki M, Iwagami S, Miyamoto Y, Yoshida N, Komohara Y, Watanabe M, Baba H.
Prognostic impact of PD-1 on tumor infiltrating lymphocytes in 433 resected esophageal cancers.
Ann Thorac Surg, in press.

7. Sakamoto R, Kajihara I, Mijiddorj T, Otsuka-Maeda S, Sawamura S, Nishimura Y, Kanemaru H, Kanazawa-Yamada S, Nakamura K, Honda N, Makino K, Aoi J, Igata T, Makino T, Masuguchi S, Fukushima S, Morinaga J, Komohara Y, Ihn H.
Existence of Staphylococcus aureus correlates with the progression of extramammary Paget's disease: potential involvement of interleukin-17 and M2-like macrophage polarization.
Eur J Dermatol 31: 48-54, 2021.

8. Morimoto Y, Ono S, Yoshida S, Mishima H, Kinoshita A, Tanaka T, Komohara Y, Kurotaki N, Kishino T, Okazaki Y, Ozawa H, Yoshiura KI, Imamura A.
A unique missense variant in the E1A-binding protein P400 gene is implicated in schizophrenia by whole-exome sequencing and mutant mouse models.
Transl Psychiatry 11: 132, 2021.

9. Maeshiro M, Shinriki S, Liu R, Nakachi Y, Komohara Y, Fujiwara Y, Ohtsubo K, Yoshida R, Iwamoto K, Nakayama H, Matsui H.
Colonization of distant organs by tumor cells generating circulating homotypic clusters adaptive to fluid shear stress.
Sci Rep 11: 6150, 2021.

10. Kumamoto K, Tasaki T, Ohnishi K, Shibata M, Shimajiri S, Harada M, Komohara Y, Nakayama T.
CD169 Expression on Lymph Node Macrophages Predicts in Patients With Gastric Cancer.
Front Oncol 11:636751, 2021.

11. Fujiwara Y, Maeda R, Takeshita H, Komohara Y.
Alginates as food ingredients absorb extra salt in sodium chloride-treated mice.
Heliyon 7: e06551, 2021.

12. Komohara Y, Miyamura T, Miyashita A, Shigeta H, Nakagawa T, Fukushima S.
An Autopsy Case of Metastatic Melanoma Originating from the Nasal Cavity That Was Treated With Nivolumab and Ipilimumab.
Cancer Diagnosis and Prognosis 1: 7-12, 2021.

13. Tsukamoto H, Komohara Y, Oshiumi H.
The role of macrophages in anti-tumor immune responses: pathological significance and potential as therapeutic targets.
Hum Cell 34: 1031-1039, 2021.

14. Yamamura K, Beppu T, Oda E, Sato N, Yuki H, Motohara T, Miyamoto H, Miyamura S, Onishi K, Komohara Y, Akahoshi S.
Hepatic Inflammatory Pseudotumor Mimicking Malignant Tumor With Rare Onset of Intra-abdominal Hemorrhage.
Anticancer Res 41: 2727-2732, 2021.

15. Sato M, Kadomatsu T, Miyata K, Warren JS, Tian Z, Zhu S, Horiguchi H, Makaju A, Bakhtina A, Morinaga J, Sugizaki T, Hirashima K, Yoshinobu K, Imasaka M, Araki M, Komohara Y, Wakayama T, Nakagawa S, Franklin S, Node K, Araki K, Oike Y.
The lncRNA Caren antagonizes heart failure by inactivating DNA damage response and activating mitochondrial biogenesis.
Nat Commun 12: 2529, 2021.

16. Miura Y, Anami T, Yatsuda J, Motoshima T, Oka S, Suyama K, Inoshita N, Kinowaki K, Urakami S, Kamba T, Komohara Y.
HLA-DR and CD74 Expression and the Immune Microenvironment in Renal Cell Carcinoma.
Anticancer Res, 41: 2841-2848, 2021.

17. Nohara T, Fujiwara Y, El-Aasr M, Ikeda T, Ono M, Nakano D, Kinjo J.
Thiolane-type sulfides from garlic, onion, and Welsh onion.
J Nat Med 75: 741-751, 2021.

18. Anami T, Komohara Y, Miura Y, Yamanaka K, Kurahashi R, Segawa T, Motoshima T, Murakami Y, Yatsuda J, Yamaguchi T, Sugiyama Y, Jinnouchi Y, Kamba T.
High T-cell infiltration in tumor tissue and younger age predict the response to pembrolizumab in recurrent urothelial cancer.
Med Mol Morpho, in press.

19. Harada M, Iida Y, Kotani H, Minami T, Komohara Y, Eto M, Yoshikawa K, Uemura H.
T-cell responses and combined immunotherapy against human carbonic anhydrase 9-expressing mouse renal cell carcinoma.
Cancer Immunol Immunother, in press.

20. Matsusaka K, Fujiwara Y, Pan C, Esumi S, Saito Y, Bi J, Nakamura Y, Mukunoki A, Takeo T, Nakagata N, Yoshii D, Fukuda R, Nagasaki T, Tanaka R, Komori H, Maeda H, Watanabe H, Tamada K, Komohara Y, Maruyama T.
α1-acid glycoprotein enhances the immunosuppressive and protumor functions of tumor-associated macrophages.
Cancer Res 81:4545-4559, 2021.

21. Matsubara E, Komohara Y, Shinchi Y, Mito R, Fujiwara Y, Ikeda K, Shima T, Shimoda M, Kanai Y, Sakagami T, Suzuki M.
CD163-positive cancer cells are a predictor of a worse clinical course in lung adenocarcinoma.
Pathol Int, in press.

22. Sato R, Imamura K, Semba T, Tomita Y, Saeki S, Ikeda K, Komohara Y, Suzuki M, Sakagami T, Saya H, Arima Y.
TGF-β signaling activated by cancer-associated fibroblasts determines the histological signature of lung adenocarcinoma.
Cancer Res 81: 4751-4765, 2021.

23. Fujiwara Y, Okada S, Uryu K, Maru I, Komohara Y.
The extract of Ilex kudingcha inhibits atherosclerosis in apoE-deficient mice by suppressing cholesterol accumulation in macrophages.
Biosci Biotechnol Biochem 85: 2177-2184, 2021.

24. Hara Y, Yamamura K, Matsumura K, Oda E, Akahoshi S, Yuki H, Tomiguchi J, Motohara T, Miyamoto H, Komohara Y, Beppu T.
Laparoscopic Surgery for a Patient With Multiple Liver Metastases of Unknown Origin Concomitant With Gallbladder Tumor.
In Vivo 35: 2963-2968, 2021.

25. Sakamoto Y, Mima K, Ishimoto T, Ogata Y, Imai K, Miyamoto Y, Akiyama T, Daitoku N, Hiyoshi Y, Iwatsuki M, Baba Y, Iwagami S, Yamashita YI, Yoshida N, Komohara Y, Ogino S, Baba H.
The relationship of Fusobacterium nucleatum with antitumour immunity in colorectal cancer liver metastasis.
Cancer Sci, in press.

26. Yonemitsu K, Miyasato Y, Shiota T, Shinchi Y, Fujiwara Y, Hosaka S, Yamamoto Y, Komohara Y.
Soluble Factors Involved in Cancer Cell-Macrophage Interaction Promote Breast Cancer Growth.
Anticancer Res 41: 4249-4258, 2021.

27. Komohara Y, Anami T, Asano K, Fujiwara Y, Yatsuda J, Kamba T.
Anti-Cancer Immune Reaction and Lymph Node Macrophage; A Review from Human and Animal Studies.
Immuno 1: 223-230, 2021.

28. Matsumoto C, Iwatsuki M, Iwagami S, Morinaga T, Yamashita K, Nakamura K, Eto K, Kurashige J, Baba Y, Miyamoto Y, Yoshida N, Komohara Y, Baba H.
Prophylactic laparoscopic total gastrectomy for gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS): the first report in Asia.
Gastric Cancer, in press.

29. Kosaka A, Ishibashi K, Nagato T, Kitamura H, Fujiwara Y, Yasuda S, Nagata M, Harabuchi S, Hayashi R, Yajima Y, Ohara K, Kumai T, Aoki N, Komohara Y, Oikawa K, Harabuchi Y, Kitada M, Kobayashi H, Ohkuri T.
CD47 blockade enhances the efficacy of intratumoral STING-targeting therapy by activating phagocytes.
J Exp Med 218: e20200792, 2021.

30. Kai K, Komohara Y, Esumi S, Fujiwara Y, Yamamoto T, Uekawa K, Ohta K, Takezaki T, Kuroda J, Shinojima N, Hamasaki T, Mukasa A.
Macrophage/microglia-derived IL-1β induces glioblastoma growth via the STAT3/NF-κB pathway.
Hum Cell, in press.

31. Oda E, Yamamura K, Hara Y, Matsumura K, Akahoshi S, Yuki H, Motohara T, Miyamoto H, Kinoshita K, Matsumura F, Ohnishi K, Komohara Y, Beppu T.
Intrahepatic Cholangiocarcinoma Coexisting With Multiple Bile Duct Adenoma Treated as Liver Metastasis from a Pancreatic Neuroendocrine Tumor.
Anticancer Res 41: 5249-5254, 2021.

2020
1. Yamashita K, Iwatsuki M, Harada K, Eto K, Hiyoshi Y, Ishimoto T, Nagai Y, Iwagami S, Miyamoto Y, Yoshida N, Komohara Y, Ajani JA, Baba H.
Prognostic impacts of the combined positive score and the tumor proportion score for programmed death ligand-1 expression by double immunohistochemical staining in patients with advanced gastric cancer.
Gastric Cancer 23: 95-104, 2020.

2. Urata K, Kajihara I, Miyauchi H, Mijiddorj T, Otsuka-Maeda S, Sakamoto R, Sawamura S, Kanemaru H, Kanazawa-Yamada S, Makino K, Aoi J, Makino T, Fukushima S, Komohara Y, Ihn H.
The Warburg effect and tumor immune microenvironment in extramammary Paget's disease: Overexpression of LDHA correlates with immune resistance.
J Eur Acad Dermatol Venereol 34:1715-1721, 2020.

3. Terashima Y, Toda E, Itakura M, Otsuji M, Yoshinaga S, Okumura K, Shand FHW, Komohara Y, Takeda M, Kokubo K, Chen MC, Yokoi S, Rokutan H, Kofuku Y, Ohnishi K, Ohira M, Iizasa T, Nakano H, Okabe T, Kojima H, Shimizu A, Kanegasaki S, Zhang MR, Shimada I, Nagase H, Terasawa H, Matsushima K.
Targeting FROUNT with disulfiram suppresses macrophage accumulation and its tumor-promoting properties.
Nat Commun 11: 609, 2020.

4. Mito R, Matsubara E, Komohara Y, Shinchi Y, Sato K, Yoshii D, Ohnishi K, Fujiwara Y, Tomita Y, Ikeda K, Sakagami T, Suzuki M.
Clinical impact of TROP2 in non-small lung cancers and its correlation with abnormal p53 nuclear accumulation.
Pathol Int 70: 287-294, 2020.

5. Hide T, Komohara Y.
Oligodendrocyte Progenitor Cells in the Tumor Microenvironment.
Adv Exp Med Biol 1234:107-122, 2020.

6. Kim MW, Lee G, Niidome T, Komohara Y, Lee R, Park YI.
Platelet-Like Gold Nanostars for Cancer Therapy: The Ability to Treat Cancer and Evade Immune Reactions.
Front Bioeng Biotechnol 8: 133, 2020.

7. Okadome K, Baba Y, Nomoto D, Yagi T, Kalikawe R, Harada K, Hiyoshi Y, Nagai Y, Ishimoto T, Iwatsuki M, Iwagami S, Miyamoto Y, Yoshida N, Watanabe M, Komohara Y, Shono T, Sasaki Y, Baba H.
Prognostic and clinical impact of PD-L2 and PD-L1 expression in a cohort of 437 oesophageal cancers.
Br J Cancer 122: 1535-1543, 2020.

8. Pan C, Fujiwara Y, Horlad H, Shiraishi D, Iriki T, Tsuboki J, Ikeda T, Komohara Y.
Flavonoid Compounds Contained in Epimedii Herba Inhibit Tumor Progression by Suppressing STAT3 Activation in the Tumor Microenvironment.
Front Pharmacol 11:262, 2020.

9. Kaida T, Beppu T, Hayashi H, Imai K, Yamamura K, Okabe H, Matsumura K, Yoshii D, Komohara Y, Akahoshi S, Doi K, Yamashita YI, Baba H.
Inflammatory Liver Tumor Caused by Fasciola hepatica Mimicking Intrahepatic Cholangiocarcinoma.
Anticancer Res 40: 2795-2800, 2020.

10. Suzuki R, Fujiwara Y, Saito M, Arakawa S, Shirakawa JI, Yamanaka M, Komohara Y, Marumo K, Nagai R.
Intracellular Accumulation of Advanced Glycation End-Products Induces Osteoblast Apoptosis via Endoplasmic Reticulum Stress.
J Bone Miner Res 35: 1992-2003, 2020.

11. Yoshii D, Inomata Y, Komohara Y, Shimata K, Honda M, Hayashida S, Oya Y, Yamamoto H, Yamamoto H, Sugawara Y, Hibi T.
Ki67 Expression at Kasai Portoenterostomy as a Prognostic Factor in Patients With Biliary Atresia.
BJS Open 4: 873-883, 2020.

12. Yoshida M, Utsunomiya D, Takada S, Komohara Y, Mizoshiri T, Oda S, Harada K, Ikeda O.
The Imaging Findings of Peliosis Hepatis on Gadoxetic Acid Enhanced MRI.
Radiol Case Rep 15: 1261-1265, 2020.

13. Sawayama H, Komohara Y, Hirao H, Sakata K, Takata N, Yoshinaka I, Harada K, Baba H.
Nivolumab Exerts Therapeutic Effects Against Metastatic Lesions From Early Gastric Adenocarcinoma With a Small Proportion of Neuroendocrine Carcinoma After Gastrectomy: A Case Report.
Clin J Gastroenterol 13: 759-765, 2020.

14. Oda E, Beppu T, Kinoshita K, Yamamura K, Sato N, Yuki H, Chiyonaga S, Motohara T, Komohara Y, Akahoshi S.
Hepatic Xanthogranuloma That Originated From a Liver Cyst and Mimicked a Malignant Tumor.
In Vivo 34: 2067-2071, 2020.

15. Uchihara T, Miyake K, Yonemura A, Komohara Y, Itoyama R, Koiwa M, Yasuda T, Arima K, Harada K, Eto K, Hayashi H, Iwatsuki M, Iwagami S, Baba Y, Yoshida N, Yashiro M, Masuda M, Ajani JA, Tan P, Baba H, Ishimoto T.
Extracellular Vesicles From Cancer-Associated Fibroblasts Containing Annexin A6 Induces FAK-YAP Activation by Stabilizing β1 Integrin, Enhancing Drug Resistance.
Cancer Res 80: 3222-3235, 2020.

16. Ishiuchi K, Amber Syed A, Kosuge Y, Fujiwara Y, Makino T, Hirose D.
Decaturenol A and known oxalicine related meroterpenoids isolated from Penicillium decaturense RO050, and their new biological activities.
Bioorg Med Chem Lett 30, 2020.

17. Komohara Y, Harada M, Ohnishi K, Kumamoto K, Nakayama T.
PD-L1 expression in regional lymph nodes and predictable roles in anti-cancer immune responses.
J Clin Exp Hematop 60: 113-116, 2020.

18. Akahoshi S, Yamamura K, Sato N, Oda E, Kinoshita K, Yuki H, Motohara T, Deguchi A, Komohara Y, Beppu T.
A hepatic sclerosed hemangioma with drastic changes in contrast-enhanced ultrasonography.
Clin J Gastroenterol 13: 1252-1257, 2020.

19. Dewi AK, Anwar C, Komohara Y.
Brain structure morphology after being fixated with ethanol on electron microscope.
Int J Morphol 38: 305-308, 2020.

20. Kurahashi R, Motoshima T, Fukushima Y, Murakami Y, Tatsuda J, Yamaguchi T, Sugiyama Y, Fukushima S, Komohara Y, Suekane S, Kamba T.
Remarkable antitumor effect of nivolumab in a patient with metastatic renal cell carcinoma previously treated with a peptide‐based vaccine.
IJU Case Reports 3: 44-48, 2020.

21. Morikawa K, Takashio S, Sato R, Yamamoto E, Kaikita K, Tsujita K, Komohara Y.
Extensive Loss of Myocardium due to Lymphocytic Fulminant Myocarditis: An Autopsy Case Report of a Patient with Persistent Cardiac Arrest for 25 Days.
Intern Med 59: 3171-3175, 2020.

22. Yamamura K, Beppu T, Sato N, Kinoshita K, Oda E, Yuki H, Motohara T, Miyamoto H, Komohara Y, Akahoshi S.
Complete Removal of Adrenal Metastasis in Hepatocellular Carcinoma Using Indocyanine Green Fluorescent Imaging.
Anticancer Res 40: 5823-5828, 2020.

23. Fujiwara Y, Ohnishi K, Horlad H, Saito Y, Shiraishi D, Takeya H, Yoshii D, Kaieda S, Hoshino T, Komohara Y.
CD163 deficiency facilitates lipopolysaccharide-induced inflammatory responses and endotoxin shock in mice.
Clin Transl Immunology 9: e1162, 2020.

24. Kai K, Komohara Y, Shinojima N, Yano S, Mikami Y, Yokoo H, Mukasa A.
A case of suprasellar Erdheim-Chester disease and characterization of macrophage phenotype.
J Clin Exp Hematop 60: 179-182, 2020.

25. Morita Y, Senokuchi T, Yamada S, Wada T, Furusho T, Matsumura T, Ishii N, Nishida S, Nishida S, Motoshima H, Komohara Y, Yamagata K, Araki E.
Impact of tissue macrophage proliferation on peripheral and systemic insulin resistance in obese mice with diabetes.
BMJ Open Diabetes Res Care 8: e001578, 2020.

26. Yamamura K, Beppu T, Kinoshita K, Oda E, Sato N, Yuki H, Motohara T, Miyamoto H, Kawaguchi H, Komohara Y, Akahoshi S.
Hepatocellular Carcinoma With Extensive Cancer-associated Thrombosis Successfully Treated With Liver Resection and Direct Oral Anticoagulant: A Case Report.
Anticancer Res 40: 6465-6471, 2020.

27. Sato N, Yamamura K, Oda E, Akahoshi S, Yuki H, Motohara T, Miyamoto H, Yoshii D, Komohara Y, Beppu T.
Cholangiolocarcinoma With Multiple Recurrences Successfully Treated With Repeated Liver Resection and Radiofrequency Ablation.
Anticancer Res 40: 7147-7153, 2020.

28. Fujimura R, Watanabe H, Nishida K, Fujiwara Y, Koga T, Bi J, Imafuku T, Kobayashi K, Komori H, Miyashita M, Maeda H, Tanaka M, Matsuhita K, Wada T, Fukagawa M, Maruyama T.
α1-Acid Glycoprotein Attenuates Adriamycin-Induced Nephropathy via CD163 Expressing Macrophage Induction.
Kidney360 1: 343-353, 2020.

29. Nakanishi Y, Nakashima Y. Fujiwara Y. Komohara Y, Hino K, Miura H, Higaki H.
Microfluidic Device used for the Secretion of Inflammatory Cytokines from Human Monocyte-Derived Macrophages Stimulated by Ultra-High Molecular Weight Polyethylene Particles.
Biotribology 23: 100137, 2020.

30. Xiao Y, Xu W, Komohara Y, Fujiwara Y, Hirose H, Futaki S, Niidome T.
Effect of Surface Modifications on Cellular Uptake of Gold Nanorods in Human Primary Cells and Established Cell Lines.
ACS Omega 5: 32744-32752, 2020.

31. Marumoto M, Sakamoto M, Marumoto K, Tsuruta S, Komohara Y.
Mercury and Selenium Localization in the Cerebrum, Cerebellum, Liver, and Kidney of a Minamata Disease Case.
Acta Histochem Cytochem 53: 147-155, 2020.

2019
1. Komohara Y, Takeya H, Wakigami N, Kusada N, Bekki H, Ishihara S, Takeya M, Nakashima Y, Oda Y.
Positive correlation between the density of macrophages and T-cells in undifferentiated sarcoma.
Med Mol Morphol 52: 44-51, 2019.

2. Higuchi Y, Niidome T, Miyamoto Y, Komohara Y, Tokunou T, Kubota T, Horiuchi T.
Accumulation of gold nano-rods in the failing heart of transgenic mice with the cardiac-specific expression of TNF-α.
Heart Vessels 34: 538-544, 2019.

3. Yamamoto M, Motomura E, Yanagisawa, R, Hoang VAT, Mogi M, Mori T, Nakamura M, Takeya M, Eto K.
Evaluation of Neurobehavioral Impairment in Methylmercury-Treated KK-Ay Mice by Dynamic Weight- Bearing Test.
J Appl Toxicol 39: 221-230, 2019.

4. Tsukamoto M, Imai K, Ishimoto T, Komohara Y, Yamashita YI, Nakagawa S, Umezaki N, Yamao T, Kitano Y, Miyata T, Arima K, Okabe H, Baba Y, Chikamoto A, Ishiko T, Hirota M, Baba H.
PD-L1 expression enhancement by infiltrating macrophage-derived TNF-α leads to poor pancreatic cancer prognosis.
Cancer Sci 110; 310-320, 2019.

5. Maeda-Otsuka S, Kajihara I, Tasaki Y, Yamada-Kanazawa S, Sakamoto R, Sawamura S, Masuzawa M, Masuzawa M, Amoh Y, Hoshina D, Abe R, Komohara Y, Ihn H.
Hypoxia accelerates the progression of angiosarcoma through the regulation of angiosarcoma cells and tumor microenvironment.
J Dermatol Sci 93: 123-132, 2019.

6. Uto K, Sakamoto S, Que W, Shimata K, Hashimoto S, Sakisaka M, Narita Y, Yoshii D, Zhong L, Komohara Y, Li XK, Inomata Y, Hibi T.
Hydrogen-rich solution attenuates cold ischemia-reperfusion injury in rat liver transplantation.
BMC Gastroenterol 19: 25, 2019.

7. Hayashi K, Hasegawa Y, Takemoto Y, Cao C, Takeya H, Komohara Y, Mukasa A, Kim-Mitsuyama S.
Continuous intracerebroventricular injection of Porphyromonas gingivalis lipopolysaccharide induces systemic organ dysfunction in a mouse model of Alzheimer's disease.
Exp Gerontol 120: 1-5, 2019.

8. Yagi T, Baba Y, Okadome K, Kiyozumi Y, Hiyoshi Y, Ishimoto T, Iwatsuki M, Miyamoto Y, Yoshida N, Watanabe M, Komohara Y, Baba H.
Tumour-associated macrophages are associated with poor prognosis and programmed death ligand 1 expression in oesophageal cancer.
Eur J Cancer 111: 38-49, 2019.

9. Nakayama W, Fujiwara Y, Kosuge Y, Monthakantirat O, Fujikawa K, Watthana S, Susumu Kitanaka, Makino T, Ishiuchi K.
Phlenumdines D and E, new Lycopodium alkaloids from Phlegmariurus nummulariifolius, and their regulatory effects on macrophage differentiation during tumor development.
Phytochem Lett 29: 98-103, 2019.

10. Tanaka R, Saito Y, Fujiwara Y, Jo JI, Tabata Y.
Preparation of fibrin hydrogels to promote the recruitment of anti-inflammatory macrophages.
Acta Biomater 89:152-165, 2019.

11. Morimoto Y, Yoshida S, Kinoshita A, Satoh C, Mishima H, Yamaguchi N, Matsuda K, Sakaguchi M, Tanaka T, Komohara Y, Imamura A, Ozawa H, Nakashima M, Kurotaki N, Kishino T, Yoshiura KI, Ono S.
Nonsense mutation in CFAP43 causes normal-pressure hydrocephalus with ciliary abnormalities.
Neurology 92: e2364-e2374, 2019.

12. Kitano Y, Yamashita YI, Saito Y, Nakagawa S, Okabe H, Imai K, Komohara Y, Miyamoto Y, Chikamoto A, Ishiko T, Baba H.
Sarcopenia Affects Systemic and Local Immune System and Impacts Postoperative Outcome in Patients with Extrahepatic Cholangiocarcinoma.
World J Surg 43: 2271-2280, 2019.

13. Kiyozumi Y, Baba Y, Okadome K, Yagi T, Ishimoto T, Iwatsuki M, Miyamoto Y, Yoshida N, Watanabe M, Komohara Y, Baba H.
IDO1 Expression Is Associated With Immune Tolerance and Poor Prognosis in Patients With Surgically Resected Esophageal Cancer.
Ann Surg 269: 1101-1108, 2019.

14.
Murakami-Nishida S, Matsumura T, Senokuchi T, Ishii N, Kinoshita H, Yamada S, Morita Y, Nishida S, Motoshima H, Kondo T, Komohara Y, Araki E.
Pioglitazone suppresses macrophage proliferation in apolipoprotein-E deficient mice by activating PPARγ..

Atherosclerosis 286: 30-39, 2019.

15. Yamashiro S, Uchikawa H, Yoshikawa M, Kuriwaki K, Hitoshi Y, Yoshida A, Komohara Y, Mukasa A.
Histological analysis of infiltrating macrophages in the cerebral aneur ysm walls.

J Clin Neurosci 67: 204-209, 2019.

16. Yamashita K, Iwatsuki M, Harada K, Koga Y, Kiyozumi Y, Eto K, Hiyoshi Y, Ishimoto T, Iwagami S, Baba Y, Miyamoto Y, Yoshida N, Komohara Y, Ajani JA, Baba H.
Can PD-L1 expression evaluated by biopsy sample accurately reflect its expression in the whole tumour in gastric cancer?
Br J Cancer 121: 278-280, 2019.

17. Shinchi Y, Komohara Y, Yonemitsu K, Sato K, Ohnishi K, Saito Y, Fujiwara, Y, Mori T, Shiraishi K, Ikeda K, Suzuki M.
Accurate expression of PD-L1/L2 in lung adenocarcinoma cells: a retrospective study by double immunohistochemistry.
Cancer sci 110: 2711-2721, 2019.

18. Yamashita T, Ohnishi K, Ueda M, Masuda T, Inoue Y, Misumi Y, Ueda A, Obayashi K, Takeya M, Ando Y.
Transthyretin amyloid-related cerebral angiitis after liver transplantation.
Amyloid 26(sup1): 11-12, 2019.

19. Umemoto S, Haruta M, Sakisaka M, Ikeda T, Tsukamoto H, Komohara Y, Takeya M, Nishimura Y, Senju S.
Cancer therapy with MHC-deficient and interferon β-producing myeloid cells derived from allogeneic embryonic stem cells.
Cancer Sci 110: 3027-3037, 2019.

20. Baba Y, Yagi T, Kosumi K, Okadome K, Nomoto D, Eto K, Hiyoshi Y, Nagai Y, Ishimoto T, Iwatsuki M, Iwagami S, Miyamoto Y, Yoshida N, Komohara Y, Watanabe M, Baba H.
Morphological lymphocytic reaction, patient prognosis and PD-1 expression after surgical resection for oesophageal cancer.
Br J Surg 106: 1352-1361, 2019.

21. Noyori O, Komohara Y, Nasser H, Hiyoshi M, Ma C, Pan C, Carreras J, Nakamura N, Sato A, Ando K, Okuno Y, Nosaka K, Matsuoka M, Suzu S.
Expression of IL-34 correlates with macrophage infiltration and prognosis of diffuse large B-cell lymphoma.
Clin Transl Immunology 8: e1074, 2019.

22. Takeya H, Ohnishi K, Shiota T, Saito Y, Fujiwara Y, Yagi T, Kiyozumi Y, Baba Y, Yoshida N, Asano K, Tanaka M, Baba H, Komohara Y.
Maf expression in human macrophages and lymph node sinus macrophages in patients with esophageal cancer.
J Clin Exp Hematop 59: 112-118, 2019.

23. Sato N, Beppu T, Kinoshita K, Yuki H, Suyama K, Chiyonaga S, Motohara T, Komohara Y, Hara A, Akahoshi S.
Conversion Hepatectomy for Huge Hepatocellular Carcinoma With Arterioportal Shunt After Chemoembolization and Lenvatinib Therapy.
Anticancer Res 39: 5695-5701, 2019.

24. Kinoshita S, Mera K, Ichikawa H, Shimasaki S, Nagai M, Taga Y, Iijima K, Hattori S, Fujiwara Y, Shirakawa JI, Nagai R.
Nω -(Carboxymethyl)arginine Is One of the Dominant Advanced Glycation End Products in Glycated Collagens and Mouse Tissues.
Oxid Med Cell Longev 2019: 9073451, 2019.

25. Nouno T, Okamoto M, Ohnishi K, Kaieda S, Tominaga M, Zaizen Y, Ichiki M, Momosaki S, Nakamura M, Fujimoto K, Fukuoka J, Shimizu S, Komohara Y, Hoshino T.
Elevation of pulmonary CD163+ and CD204+ macrophages is associated with the clinical course of idiopathic pulmonary fibrosis patients.
J Thorac Dis 11: 4005-4017, 2019.

26. Komohara Y, Harada M.
Potential mechanisms of spontaneous regression in patients with B-cell lymphoma; the significance of co-stimulatory molecules in lymphoma cells.
J Clin Exp Hematop 59: 207-210, 2019.

2018
1. Ma C, Horlad H, Ohnishi K, Nakagawa T, Yamada S, Kitada S, Motoshima T, Kamba T, Nakayama T, Fujimoto N, Takeya M, Komohara Y.
CD163-positive cancer cells are potentially associated with high malignant potential in clear cell renal cell carcinoma.
Med Mol Morphol 51: 13-20, 2018.

2. Nohara T, Ono M, Nishioka N, Masuda F, Fujiwara Y, Ikeda T, Nakano D, Kinjo J.
New cyclic sulfides, garlicnins I2, M, N, and O, from Allium sativum.
J Nat Med 72: 326-331, 2018.

3. Kitano Y, Okabe H, Yamashita YI, Nakagawa S, Saito Y, Umezaki N, Tsukamoto M, Yamao T, Yamamura K, Arima K, Kaida T, Miyata T, Mima K, Imai K, Hashimoto D, Komohara Y, Chikamoto A, Ishiko T, Baba H.
Tumour-infiltrating inflammatory and immune cells in patients with extrahepatic cholangiocarcinoma.
Br J Cancer 118: 171-180, 2018.

4. Nohara T, Ono M, Nishioka N, Masuda F, Fujiwara Y, Ikeda T, Nakano D, Kinjo J.
New cyclic sulfides extracted from Allium sativum: garlicnins P, J2, and Q.
J Nat Med 72: 335-341, 2018.

5. Motoshima T, Miura Y, Wakigami N, Kusada N, Takano T, Inoshita N, Okaneya T, Sugiyama Y, Kamba T, Takeya M, Komohara Y.
Phenotypical change of tumor-associated macrophages in metastatic lesions of clear cell renal cell carcinoma.
Med Mol Morphol 51: 57-63, 2018.

6. Arima K, Komohara Y, Bu L, Tsukamoto M, Itoyama R, Miyake K, Uchihara T, Ogata Y, Nakagawa S, Okabe H, Imai K, Hashimoto D, Chikamoto A, Yamashita YI, Baba H, Ishimoto T.
Down-regulation of 15-PGDH by interleukin-1 beta from activated macrophages leads to poor prognosis in pancreatic cancer.
Cancer Sci 109: 462-470, 2018.

7. Omoto T, Kim-Kaneyama JR, Lei XF, Orimo A, Ohnishi K, Yoshihara K, Miyauchi A, Li S, Gao L, Umemoto T, Tanaka J, Nakahara K, Takeya M, Ishida F, Kudo SE, Haraguchi S, Miyazaki T, Miyazaki A.
The impact of stromal Hic-5 on the tumorigenesis of colorectal cancer through lysyl oxidase induction and stromal remodeling.
Oncogene 37: 1205-1219, 2018.

8. Yamada S, Senokuchi T, Matsumura T, Morita Y, Ishii N, Fukuda K, Murakami S, Nishida S, Kawasaki S, Motoshima H, Furukawa N, Komohara Y, Fujiwara Y, Koga T, Yamagata K, Takeya M, Araki E.
Inhibition of Local Macrophage Growth Ameliorates Focal Inflammation and Suppresses Atherosclerosis.
Arterioscler Thromb Vasc Biol 38: 994-1006, 2018.

9. Asano T, Ohnishi K, Shiota T, Motoshima T, Sugiyama Y, Yatsuda J, Kamba T, Ishizaka K, KomoharaY.
CD169-positive sinus macrophages in the lymph nodes determine bladder cancer prognosis.
Cancer Sci 106: 1723-1730, 2018.

10. Fujiwara Y, Saito Y, Shiota T, Cheng P, Ikeda T, Ohnishi K, Takeya M, Komohara Y.
Natural compounds that regulate lymph node sinus macrophages: Inducing an anti-tumor effect by regulating macrophage activation.
J Clin Exp Hematop 58: 17-23, 2018.

11. Hide T, Komohara Y, Miyasato Y, Nakamura H, Makino K, Takeya M, Kuratsu JI, Mukasa A, Yano S.
Oligodendrocyte Progenitor Cells and Macrophages/Microglia Produce Glioma Stem Cell Niches at the Tumor Border.
EBioMedicine 30: 94-104, 2018.

12. Shiraishi D, Fujiwara Y, Horlad H, Saito Y, Iriki T, Tsuboki J, Cheng P, Nakagata N, Mizuta H, Bekki H, Nakashima Y, Oda Y, Takeya M, Komohara Y.
CD163 is required for protumoral activation of macrophages in human and murine sarcoma.
Cancer Res 78: 3255-3266, 2018.

13. Miyasato Y, Yoshizawa T, Sato Y, Nakagawa T, Miyasato Y, Kakizoe Y, Kuwabara T, Adachi M, Ianni A, Braun T, Komohara Y, Mukoyama M, Yamagata K.
Sirtuin 7 Deficiency Ameliorates Cisplatin-induced Acute Kidney Injury Through Regulation of the Inflammatory Response.
Sci Rep 8: 5927, 2018.

14. Minayoshi Y, Maeda H, Yanagisawa H, Hamasaki K, Mizuta Y, Nishida K, Kinoshita R, Enoki Y, Imafuku T, Chuang VTG, Koga T, Fujiwara Y, Takeya M, Sonoda K, Wakayama T, Taguchi K, Ishima Y, Ishida T, Iwakiri Y, Tanaka M, Sasaki Y, Watanabe H, Otagiri M, Maruyama T.
Development of Kupffer cell targeting type-I interferon for the treatment of hepatitis via inducing anti-inflammatory and immunomodulatory actions.
Drug Deliv 25: 1067-1077, 2018.

15. Tanoue Y, Toyoda T, Sun J, Mustofa MK, Tateishi C, Endo S, Motoyama N, Araki K, Wu D, Okuno Y, Tsukamoto T, Takeya M, Ihn H, Vaziri C, Tateishi S.
Differential Roles of Rad18 and Chk2 in Genome Maintenance and Skin Carcinogenesis Following UV Exposure.
J Invest Dermatol 138: 2550-2557, 2018.

16. Miyasato Y, Takashima Y, Takeya H, Yano H, Hayano A, Nakagawa T, Makino K, Takeya M, Yamanaka R, Komohara Y.
The expression of PD-1 ligands and IDO1 by macrophages/microglia in primary central nervous system lymphoma.
J Clin Exp Hematop58: 95-101, 2018.

17. Imamura Y, Tashiro H, Tsend-Ayush G, Haruta M, Dashdemberel N, Komohara Y, Tsuboki J, Takaishi K, Ohba T, Nishimura Y, Katabuchi H, Senju S.
Novel therapeutic strategies for advanced ovarian cancer by using iPS cell-derived myelomonocytic cells producing interferon beta.
Cancer Sci 109: 3403-3410, 2018.

18. Endo S, Nishimura N, Kawano Y, Ueno N, Ueno S, Tatetsu H, Komohara Y, Takeya M, Hata H, Mitsuya H, Masao M, Okuno Y.
MUC1/KL-6 expression confers an aggressive phenotype upon myeloma cells.
Biochem Biophys Res Commun 507: 246-252, 2018.

19. Fujita A, Tsukaguchi H, Koshimizu E, Nakazato H, Itoh K, Kuraoka S, Komohara Y, Shiina M, Nakamura S, Kitajima M, Tsurusaki Y, Miyatake S, Ogata K, Iijima K, Matsumoto N, Miyake N.
Homozygous splicing mutation in NUP133 causes Galloway-Mowat syndrome.
Ann Neurol 84: 814-828, 2018.

20. Takamatsu K, Nakane S, Suzuki S, Kosaka T, Fukushima S, Kimura T, Miyashita A, Mukaino A, Yamakawa S, Watanabe K, Jinnin M, Komohara Y, Ihn H, Ando Y.
Immune checkpoint inhibitors in the onset of myasthenia gravis with hyperCKemia.
Ann Clin Transl Neurol 5: 1421-1427, 2018.

21. Takeya H, Shiota T, Yagi T, Ohnishi K, Baba Y, Miyasato Y, Kiyozumi Y, Yoshida N, Takeya M, Baba H, Komohara Y.
High CD169 expression in lymph node macrophages predicts a favorable clinical course in patients with esophageal cancer.
Pathol Int 68: 685-693, 2018.

22. Komohara Y, Noyori O, Saito Y, Takeya H, Baghdadi M, Kitagawa F, Hama N, Ishikawa K, Okuno Y, Nosaka K, Seino KI, Matsuoka M, Suzu S.
Potential anti-lymphoma effect of M-CSFR inhibitor in adult T-cell leukemia/lymphoma.
J Clin Exp Hematop 58: 152-160, 2018.

2017
1. Komohara Y, Ohnishi K, Takeya M.
Possible functions of CD169-positive sinus macrophages in lymph nodes in anti-tumor immune responses.
Cancer Sci 108: 290-295, 2017.

2. Sakisaka M, Haruta M, Komohara Y, Umemoto S, Matsumura K, Ikeda T, Takeya M, Inomata Y, Nishimura Y, Senju S.
Therapy of primary and metastatic liver cancer by human iPS cell-derived myeloid cells producing interferon-β.
J Hepatobiliary Pancreat Sci 24: 109-119, 2017.

3.Ono M, Fujiwara Y, Ikeda T, Pan C, El-Aasr M, Lee JH, Nakano D, Kinjo J, Nohara T.
Atypical Cyclic Sulfides, Garlicnins G, I, and J, Extracted from Allium sativum.
Chem Pharm Bull (Tokyo) 65: 102-106, 2017.

4. Motoshima T, Komohara Y, Ma C, Dewi AK, Noguchi H, Yamada S, Nakayama T, Kitada S, Kawano Y, Takahashi W, Sugimoto M, Takeya M, Fujimoto N, Oda Y, Eto M.
PD-L1 expression in papillary renal cell carcinoma.
BMC Urol 17: 8, 2017.

5. Nohara T, Fujiwara Y, El-Aasr M, Ikeda T, Ono M, Nakano D, Kinjo J.
Antitumor Allium Sulfides.
Chem Pharm Bull (Tokyo) 65: 209-217, 2017.

6. Chikamoto A, Inoue R, Komohara Y, Sakamaki K, Hashimoto D, Shiraishi S, Takamori H, Yamashita YI, Yoshida N, Yamanaka T, Yamashita Y, Baba H.
Preoperative High Maximum Standardized Uptake Value in Association with Glucose Transporter 1 Predicts Poor Prognosis in Pancreatic Cancer.
Ann Surg Oncol 24: 2040-2047, 2017.

7. Komohara Y, Fujiwara Y, Ohnishi K, Horlad H, Saito Y, Takeya M.
Recent advances in research regarding to natural compounds that target pro-tumor macrophages.
Macrophage 4, 2017.

8. Iriki T, Ohnishi K, Fujiwara Y, Horlad H, Saito Y, Pan C, Ikeda K, Mori T, Suzuki M, Ichiyasu H, Kohrogi H, Takeya M, Komohara Y.
The cell-cell interaction between tumor-associated macrophages and small cell lung cancer cells is involved in tumor progression via STAT3 activation.
Lung Cancer 106: 22-32, 2017.

9. Nishimura N, Endo S, Ueno S, Ueno N, Tatetsu H, Hirata S, Hata H, Komohara Y, Takeya M, Mitsuya H, Okuno Y.
A xenograft model reveals that PU.1 functions as a tumor suppressor for multiple myeloma in vivo.
Biochem Biophys Res Commun 486: 916-922, 2017.

10. Komohara Y, Ma, C, Yano H, Pan C, Horlad H, Saito Y, Ohnishi K, Fujiwara Y, Okuno Y, Nosaka K, Shinosaki S, Morishita K, Matsuoka M, Wakayama T, Takeya M.
Cell adhesion molecule-1 (CADM1) expressed on adult T-cell leukemia/lymphoma cells is not involved in the interaction with macrophages.
J Clin Exp Hematop 57: 15-20, 2017.

11. Ma C, Horlad H, Pan C, Yano H, Ohnishi K, Fujiwara Y, Matsuoka M, Lee A, Niidome T, Yamanaka R, Takeya M, Komohara Y.
Stat3 inhibitor abrogates the expression of PD-1 ligands on lymphoma cell lines.
J Clin Exp Hematop 57: 21-25, 2017.

12. Miyasato Y, Shiota T, Ohnishi K, Pan C, Yano H, Horlad H, Yamamoto Y, Yamamoto-Ibusuki M, Iwase H, Takeya M, Komohara Y.
The high density of CD204-positive macrophages predicts worse clinical prognosis in patients with breast cancer.
Cancer Sci 108: 1693-1700, 2017

13. Yano H, Motoshima T, Ma C, Pan C, Yamada S, Nakayama T, Kitada S, Fujimoto N, Kamba T, Takeya M, Komohara Y.
The significance of TIMD4 expression in clear cell renal cell carcinoma.
Med Mol Morphol 50: 220-226, 2017.

14. Nakagawa T, Ohnishi K, Kosaki Y, Saito Y, Horlad H, Fujiwara Y, Takeya M, Komohara Y.
Optimum immunohistochemical procedures for analysis of macrophages in human and mouse formalin fixed paraffin-embedded tissue samples.
J Clin Exp Hematop 57: 31-36, 2017.

15. Iida Y, Harashima N, Motoshima T, Komohara Y, Eto M, Harada M.
Contrasting effects of cyclophosphamide on anti-CTLA-4 blockade therapy in two mouse tumor models.
Cance Sci 108: 1974-1984, 2017.

16. Komohara Y, Kawauchi R, Makiyama E, Mikami K, Horlad H, Fujiwara Y, Kida T, Takeya M, Niidome T.
Selective depletion of cultured macrophages by magnetite nanoparticles modified with gelatin.
Exp Ther Med 14:1640-1646, 2017.

17. Hayano A, Komohara Y, Takashima Y, Takeya H, Homma J, Fukai J, Iwadate Y, Kajiwara K, Ishizawa S, Hondoh H, Yamanaka R.
Programmed Cell Death Ligand 1 Expression in Primary Central Nervous System Lymphomas: A Clinicopathological Study.
Anticancer Res 37: 5655-5666, 2017.

18. Fukuda N, Noi K, Weng L, Kobashigawa Y, Miyazaki H, Wakeyama Y, Takaki M, Nakahara Y, Tatsuno Y, Uchida-Kamekura M, Suwa Y, Sato T, Ichikawa-Tomikawa N, Nomizu M, Fujiwara Y, Ohsaka F, Saitoh T, Maenaka K, Kumeta H, Shinya S, Kojima C, Ogura T, Morioka H.
Production of Single-Chain Fv Antibodies Specific for GA-Pyridine, an Advanced Glycation End-Product (AGE), with Reduced Inter-Domain Motion.
Molecules 22: E1695, 2017.

19. Hasegawa Y, Hayashi K, Takemoto Y, Cheng C, Takane K, Lin B, Komohara Y, Kim-Mitsuyama S.
DPP-4 inhibition with linagliptin ameliorates the progression of premature aging in klotho-/- mice.
Cardiovasc Diabetol 16: 154, 2017.

20. Itoh M, Suganami T, Kato H, Kanai S, Shirakawa I, Sakai T, Goto T, Asakawa M, Hidaka I, Sakugawa H, Ohnishi K, Komohara Y, Asano K, Sakaida I, Tanaka M, Ogawa Y.
CD11c+ resident macrophages drive hepatocyte death-triggered liver fibrosis in a murine model of nonalcoholic steatohepatitis.
JCI Insight 2: e92902, 2017.

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2016
1. Fukuda R, Suico MA, Kai Y, Omachi K, Motomura K, Koga T, Komohara Y, Koyama K, Yokota T, Taura M, Shuto T, Kai H.
Podocyte p53 limits the severity of experimental Alport syndrome.
J Am Soc Nephrol 27: 144-157, 2016.

2. Komohara Y, Fujiwara Y, Ohnishi K, Shiraishi D, Takeya M.
Contribution of Macrophage Polarization to Metabolic Diseases.
J Atheroscler Thromb 23: 10-17, 2016.

3. Komohara Y, Fujiwara Y, Ohnishi K, Takeya M.
Tumor-associated macrophages: potential therapeutic targets for anti-cancer therapy. (review)
Adv Drug Deliv Rev 99: 180-185, 2016.

4. Nohara T, Fujiwara Y, Ikeda T, Murakami K, Ono M, El-Aasr M, Nakano D, Kinjo J.
Two new bicyclic sulfoxides from Welsh onion.
J Nat Med 70: 260-265, 2016.

5. Kuwahara K, Yamamoto-Ibusuki M, Zhang Z, Phimsen S, Gondo N, Yamashita H, Takeo T, Nakagata N, Yamashita D, Fukushima Y, Yamamoto Y, Iwata H, Saya H, Kondo E, Matsuo K, Takeya M, Iwase H, Sakaguchi N.
GANP protein encoded on human chromosome 21/mouse chromosome 10 is associated with resistance to mammary tumor development.
Cancer Sci 107: 469-477, 2016.

6. Nakashima K, Miyashita H, Yoshimitsu H, Fujiwara Y, Nagai R, Ikeda T.
Two new prenylflavonoids from Epimedii Herba and their inhibitory effects on advanced glycation end-products.
J Nat Med 70: 290-295, 2016.

7. Ma C, Komohara Y, Ohnishi K, Shimoji T, Kuwahara N, Sakumura Y, Matsuishi K, Fujiwara Y, Motoshima T, Takahashi W, Yamada S, Kitada S, Fujimoto N, Nakayama T, Eto M, Takeya M.
Infiltration of tumor-associated macrophages is involved in CD44 expression in clear cell renal cell carcinoma.
Cancer Sci 107: 700-707, 2016.

8. Ohnishi K, Yamaguchi M, Erdenebaatar C, Saito F, Tashiro H, Katabuchi H, Takeya M, Komohara Y.
Prognostic significance of CD169-positive lymph node sinus macrophages in patients with endometrial carcinoma.
Cancer Sci 107: 846-852, 2016.

9. Motoshima T, Komohara Y, Horlad H, Tsukamoto H, Fujita M, Saito Y, Tanoue K, Kasejima Y, Sugiyama Y, Kawano Y, Nishimura Y, Takeya M, Eto M.
CXCL10 and CCL2 mRNA expression in monocytes is inversely correlated with the HLA-DR lower fraction of monocytes in patients with renal cell carcinoma.
Oncol Lett 11: 1911-1916, 2016.

10. Yamanaka M, Matsumura T, Ohno R, Fujiwara Y, Shinagawa M, Sugawa H, Hatano K, Shirakawa J, Kinoshita H, Ito K, Sakata N, Araki E, Nagai R.
Non-invasive measurement of skin autofluorescence to evaluate diabetic complications.
J Clin Biochem Nutr 58: 135-140, 2016.

11. Arima K, Okabe H, Hashimoto D, Chikamoto A, Tsuji A, Yamamura K, Kitano Y, Inoue R, Kaida T, Higashi T, Taki K, Imai K, Komohara Y, Beppu T, Takeya M, Baba H.
The diagnostic role of the neutrophil-to-lymphocyte ratio in predicting pancreatic ductal adenocarcinoma in patients with pancreatic diseases.
Int J Clin Oncol, in press.

12. Ishiuchi K, Jiang WP, Fujiwara Y, Wu JB, Kitanaka S.
Serralongamines B-D, three new Lycopodium alkaloids from Lycopodium serratum var. longipetiolatum, and their inhibitory effects on foam cell formation in macrophages.
Bioorg Med Chem Lett 26: 2636-2640, 2016.

13. Fujiwara Y, Horlad H, Shiraishi D, Tsuboki J, Kudo R, Ikeda T, Nohara T, Takeya M, Komohara Y.
Onionin A, a sulfur-containing compound isolated from onions, impairs tumor development and lung metastasis by inhibiting the protumoral and immunosuppressive functions of myeloid cells.
Mol Nutr Food Res 60: 2467-2480, 2016.

14. Tsuboki J, Fujiwara Y, Horlad H, Shiraishi D, Nohara T, Tayama S, Motohara T, Saito Y, Ikeda T, Takaishi K, Tashiro H, Yonemoto Y, Katabuchi H, Takeya M, Komohara Y.
Onionin A inhibits ovarian cancer progression by suppressing cancer cell proliferation and the protumour function of macrophages.
Sci Rep 6: 29588, 2016.

15. Takeya M, Komohara Y.
Role of tumor-associated macrophages in human malignancies: friend or foe?
Pathol Int 66: 491-505, 2016.

16. Horlad H, Ohnishi K, Ma C, Fujiwara Y, Niino D, Ohshima K, Jinushi M, Matsuoka M, Takeya M, Komohara Y.
TIM-3 expression in lymphoma cells predicts chemoresistance in patients with adult T-cell leukemia/lymphoma (ATLL).
Oncol Lett 12: 1519-1524, 2016.

17. Miyazaki T, Tonami K, Hata S, Aiuchi T, Ohnishi K, Lei XF, Kim-Kaneyama JR, Takeya M, Itabe H, Sorimachi H, Kurihara H, Miyazaki A.
Calpain-6 confers atherogenicity to macrophages by dysregulating pre-mRNA splicing.
J Clin Invest 126: 3417-3432, 2016.

18. Sueta D, Sugamura K, Shimizu H, Shiota T, Yamamuro M, Hirakawa K, Sakamoto K, Tsujita K, Hanatani S, Yamamoto E, Araki S, Kanazawa H, Kojima S, Kaikita K, Hokimoto S, Komohara Y, Ogawa H.
A rare case of long-term survival with idiopathic dilatation of the pulmonary artery.
Int J Cardiol 223: 337-339, 2016.

19. Hasita H, Ma C, Yano H, Pan C, Ohnishi K, Fujiwara Y, Endo S, Kikukawa Y, Okuno Y, Matsuoka M, Takeya M, Komohara Y.
An IL-27/Stat3 axis induces expression of programmed cell death 1 ligands (PD-L1/2) on infiltrating macrophages in lymphoma.
Cancer Sci 107: 1696-1704, 2016.

20. Takaki M, Tanaka T, Komohara Y, Tsuchihashi Y, Mori D, Hayashi K, Fukuoka J, Yamasaki N, Nagayasu T, Ariyoshi K, Morimoto K, Nakata K.
Recurrence of pulmonary alveolar proteinosis after bilateral lung transplantation in a patient with a nonsense mutation in CSF2RB.
Respir Med Case Rep 19: 89-93, 2016.

21. Nitta H, Shimose T, Emi Y, Imamura T, Ohnishi K, Kusumoto T, Yamamoto M, Fukuzawa K, Takahashi I, Higashi H, Tsuji A, Akagi Y, Oki E, Maehara Y, Baba H; Kyushu Study Group of Clinical Cancer (KSCC) ancillary study.
Expression of the anaphylatoxin C5a receptor in gastric cancer: implications for vascular invasion and patient outcomes.
Med Oncol 33: 118, 2016.

22. Tian Z, Miyata K, Kadomatsu T, Horiguchi H, Fukushima H, Tohyama S, Ujihara Y, Okumura T, Yamaguchi S, Zhao J, Endo M, Morinaga J, Sato M, Sugizaki T, Zhu S, Terada K, Sakaguchi H, Komohara Y, Takeya M, Takeda N, Araki K, Manabe I, Fukuda K, Otsu K, Wada J, Murohara T, Mohri S, Yamashita JK, Sano M, Oike Y.
ANGPTL2 activity in cardiac pathologies accelerates heart failure by perturbing cardiac function and energy metabolism.
Nat Commun 7: 13016, 2016.

23. Wu Y, Wei FY, Kawarada L, Suzuki T, Araki K, Komohara Y, Fujimura A, Kaitsuka T, Takeya M, Oike Y, Suzuki T, Tomizawa K.
Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury.
PLoS Genet 12: e1006355, 2016.

24. Suenaga G, Ikeda T, Komohara Y, Takamatsu K, Kakuma T, Tasaki M, Misumi Y, Ueda M, Ito T, Senju S, Ando Y.
Involvement of Macrophages in the Pathogenesis of Familial Amyloid Polyneuropathy and Efficacy of Human iPS Cell-Derived Macrophages in Its Treatment.
PLoS One 11: e0163944, 2016.

25. Komohara Y, Takeya M.
CAFs and TAMs: Maestros of the tumour microenvironment.
J Pathol 240: 211-223, 2016.

26. Shiota T, Miyasato Y, Ohnishi K, Yamamoto-Ibusuki M, Yamamoto Y, Iwase H, Takeya M, Komohara Y.
The Clinical Significance of CD169-Positive Lymph Node Macrophage in Patients with Breast Cancer.
PLoS One 11: e0166680, 2016.

27. Fujiwara Y, Hizukuri Y, Yamashiro K, Makita N, Ohnishi K, Takeya M, Komohara Y, Hayashi Y.
Guanylate-binding protein 5 is a marker of interferon-γ- induced classically activated macrophages.
Clin Transl Immunology 5: e111, 2016

28. Komohara Y.
The role of tumor-associated microglia/macrophages in primary central nervous lymphoma: a new target for anti-lymphoma therapy?
Primary Central Nervous System Lymphoma (PCNSL): Incidence, Management and Outcomes.
Nova Science Publishers, Inc. p23-28, 2016.

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2015
1. Ishimoto T, Izumi D, Watanabe M, Yoshida N, Hidaka K, Miyake K, Sugihara H, Sawayama H, Imamura Y, Iwatsuki M, Iwagami S, Baba Y, Horlad H, Komohara Y, Takeya M, Baba H.
Chronic inflammation with Helicobacter pylori infection is implicated in CD44 overexpression through miR-328 suppression in the gastric mucosa.
J Gastroenterol 50: 751-757, 2015.

2. Arita-Okubo S, Kim-Kaneyama JR, Lei XF, Fu WG, Ohnishi K, Takeya M, Miyauchi A, Honda H, Itabe H, Miyazaki T, Miyazaki A.
Role of Hic-5 in the formation of microvilli-like structures and the monocyte-endothelial interaction that accelerates atherosclerosis.
Cardiovasc Res 105: 361-371, 2015.

3. Jinushi M, Komohara Y.
Tumor-associated macrophages as an emerging target against tumors: Creating a new path from bench to bedside. [Review on Cancer]
Biochim Biophys Acta 1855: 124-130, 2015.

4. Komohara Y, Niino D, Ohnishi K, Ohshima K, Takeya M.
Role of tumor-associated macrophages in hematological malignancies. (Review)
Pathol Int 65: 170-176, 2015.

5. Nohara T, Fujiwara Y, Komota Y, Kondo Y, Saku T, Yamaguchi K, Komohara Y, Takeya M.
Cyclic Sulfoxides-Garlicnins K1, K2, and H1-Extracted from Allium sativum.
Chem Pharm Bull (Tokyo) 63: 117-121, 2015

6. Ohmoto T, Yoshitani N, Nishitsuji K, Takayama T, Yanagisawa Y, Takeya M, Sakashita N.
CD44-expressing undifferentiated carcinoma with rhabdoid features of the pancreas: Molecular analysis of aggressive invasion and metastasis.
Pathol Int 65: 264-270, 2015.

7. Takamoto H, Eguchi K, Kawabata T, Fujiwara Y, Takeya M, Tsukamoto S.
Inhibitors for cholesterol ester accumulation in macrophages from Chinese cabbage.
Biosci Biotechnol Biochem 79: 1315-1319, 2015.

8. Kosumi K, Baba Y, Ishimoto T, Harada K, Miyake K, Izumi D, Tokunaga R, Murata A, Eto K, Sugihara H, Shigaki H, Iwagami S, Sakamoto Y, Miyamoto Y, Yoshida N, Watanabe M, Komohara Y, Takeya M, Baba H.
Relationship between LINE-1 hypomethylation and Helicobacter pylori infection in gastric mucosae.
Med Oncol 32: 117, 2015.

9. Komohara Y, Morita T, Annan DA, Horlad H, Ohnishi K, Yamada S, Nakayama T, Kitada S, Suzu S, Kinoshita I, Dosaka-Akita H, Akashi K, Takeya M, Jinushi M.
The coordinated actions of TIM-3 on cancer and myeloid cells in the regulation of tumorigenicity and clinical prognosis in clear cell renal cell carcinomas.
Cancer Immunol Res 3: 999-1007, 2015.

10. Motoshima T, Komohara Y, Horlad H, Takeuchi A, Maeda Y, Tanoue K, Kawano Y, Harada M, Takeya M, Eto M.
Sorafenib enhances the anti-tumor effect of anti-CTLA-4 antibody by inhibiting myeloid-derived suppressor cells.
Oncol Rep 33: 2947-2953, 2015.

11. Enoki Y, Ishima Y, Tanaka R, Sato K, Kimachi K, Shirai T, Watanabe H, Chuang VT, Fujiwara Y, Takeya M, Otagiri M, Maruyama T.
Pleiotropic Effects of Levofloxacin, Fluoroquinolone Antibiotics, against Influenza Virus-Induced Lung Injury.
PLoS One 10: e0130248, 2015.

12. Saito Y, Ohnishi K, Miyashita A, Nakahara S, Fujiwara Y, Horlad H, Motoshima T, Fukushima S, Jinnin M, Ihn H, Takeya M, Komohara Y.
Prognostic significance of CD169+ lymph node sinus macrophages in patients with malignant melanoma.
Cancer Immunol Res 3: 1356-1363, 2015.

13. Eguchi K, Kato H, Fujiwara Y, Losung F, Mangindaan RE, de Voogd NJ, Takeya M, Tsukamoto S.
Bastadins, brominated-tyrosine derivatives, suppress accumulation of cholesterol ester in macrophages.
Bioorg Med Chem Lett 25: 5389-5392, 2015.

14. Nohara T, Fujiwara Y, Zhou JR, Urata J, Ikeda T, Murakami K, El-Aasr M, Ono M.
Saponins, Esculeosides B-1 and B-2, in Tomato Juice and Sapogenol, Esculeogenin B1.
Chem Pharm Bull (Tokyo) 63: 848-850, 2015.

15. Arima K, Okabe H, Hashimoto D, Chikamoto A, Kuroki H, Taki K, Kaida T, Higashi T, Nitta H, Komohara Y, Beppu T, Takeya M, Baba H.
The Neutrophil-to-Lymphocyte Ratio Predicts Malignant Potential in Intraductal Papillary Mucinous Neoplasms.
J Gastrointest Surg 19: 2171-2177, 2015.

16. Fujiwara Y, Shiraishi D, Yoshitomi M, Ikeda T, Mizuta H, Takeya M, Komohara Y.
Soyasapogenols contained in soybeans suppress tumour progression by regulating macrophage differentiation into the protumoural phenotype.
J Funct Foods 19: 594-605, 2015.

17. Oda E, Hashimoto D, Shiomi Y, Ohnishi K, Hayashi H, Chikamoto A, Takeya M, Baba H.
A case of occult intrahepatic cholangiocarcinoma diagnosed by autopsy.
Surg Case Rep 1: 101, 2015.

18. Sueta D, Sugamura K, Shimizu H, Shiota T, Yamamuro M, Hirakawa K, Sakamoto K, Tsujita K, Hanatani S, Yamamoto E, Araki S, Kanazawa H, Kojima S, Kaikita K, Hokimoto S, Komohara Y, Ogawa H.
A rare case of long-term survival with idiopathic dilatation of the pulmonary artery.
Int J Cardiol, in press.

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2014
1. Komohara Y, Jinushi M, Takeya M.
Clinical significance of macrophage heterogeneity in human malignant tumors.
Cancer Sci 105: 1-8, 2014.

2. Kaku Y, Imaoka H, Morimatsu Y, Komohara Y, Ohnishi K, Oda H, Takenaka S, Matsuoka M, Kawayama T, Takeya M, Hoshino T.
Overexpression of CD163, CD204 and CD206 on alveolar macrophages in the lungs of patients with severe chronic obstructive pulmonary disease.
PLos One 9: e87400, 2014.

3. Noguchi H, Yamada S, Nabeshima A, Guo X, Tanimoto A, Wang KY, Kitada S, Tasaki T, Takama T, Shimajiri S, Horlad H, Komohara Y, Izumi H, Kohno K, Ichijo H, Sasaguri Y.
Depletion of apoptosis signal-regulating kinase 1 prevents bile duct ligation-induced necro-inflammation and subsequent peribiliary fibrosis.
Am J Pathol 184: 644-661, 2014.

4. Yamamoto M, Yanagisawa R, Motomura E, Nakamura M, Sakamoto M, Takeya M, Eto K.
Increased methylmercury toxicity related to obesity in diabetic KK-Ay mice.
J Appl Toxicol 34: 914-923, 2014.

5. Ishimoto T, Sugihara H, Watanabe M, Sawayama H, Iwatsuki M, Baba Y, Okabe H, Hidaka K, Yokoyama N, Miyake K, Yoshikawa M, Nagano O, Komohara Y, Takeya M, Saya H, Baba H.
Macrophage-derived reactive oxygen species suppress miR-328 targeting CD44 in cancer cells and promote redox adaptation.
Carcinogenesis 35: 1003-1011, 2014.

6. Horio E, Kadomatsu T, Miyata K, Arai Y, Hosokawa K, Doi Y, Ninomiya T, Horiguchi H, Endo M, Tabata M, Tazume H, Tian Z, Takahashi O, Terada K, Takeya M, Hao H, Hirose N, Minami T, Suda T, Kiyohara Y, Ogawa H, Kaikita K, Oike Y.
Role of Endothelial Cell-Derived Angptl2 in Vascular Inflammation Leading to Endothelial Dysfunction and Atherosclerosis Progression.
Arterioscler Thromb Vasc Biol 34: 790-800, 2014.

7. Yoshizawa T, Karim MF, Sato Y, Senokuchi T, Miyata K, Fukuda T, Go C, Tasaki M, Uchimura K, Kadomatsu T, Tian Z, Smolka C, Sawa T, Takeya M, Tomizawa K, Ando Y, Araki E, Akaike T, Braun T, Oike Y, Bober E, Yamagata K.
SIRT7 Controls Hepatic Lipid Metabolism by Regulating the Ubiquitin-Proteasome Pathway.
Cell Metab 19: 712-721, 2014.

8. Fujiwara Y, Takeya M, Komohara Y.
A Novel Strategy for Inducing the Antitumor Effects of Triterpenoid Compounds: Blocking the Protumoral Functions of Tumor-Associated Macrophages via STAT3 Inhibition.
Biomed Res Int 2014: 348539, 2014.

9. Khan S, Rahman HN, Okamoto T, Matsunaga T, Fujiwara Y, Sawa T, Yoshitake J, Ono K, Ahmed KA, Rahaman MM, Oyama K, Takeya M, Ida T, Kawamura Y, Fujii S, Akaike T.
Promotion of atherosclerosis by Helicobacter cinaedi infection that involves macrophage-driven proinflammatory responses.
Sci Rep 4: 4680, 2014.

10. Nohara T, Manabe H, Fujiwara Y, Ikeda T, Ono M, Murakami K, Nakano D, Kinjo J, Kajimoto T.
Conversion of tomato saponins to pregnane derivatives.
Chem Pharm Bull (Tokyo) 62: 483-487, 2014.

11. Nohara T, Fujiwara Y, Ikeda T, Yamaguchi K, Manabe H, Murakami K, Ono M, Nakano D, Kinjo J.
Acyclic Sulfides, Garlicnins L-1-L-4, E, and F, from Allium sativum.
Chem Pharm Bull (Tokyo) 62: 477-482, 2014.

12. El-Desoky AH, Kato H, Eguchi K, Kawabata T, Fujiwara Y, Losung F, Mangindaan RE, de Voogd NJ, Takeya M, Yokosawa H, Tsukamoto S.
Acantholactam and Pre-neo-kauluamine, Manzamine-Related Alkaloids from the Indonesian Marine Sponge Acanthostrongylophora ingens.
J Nat Prod 77: 1536-1540, 2014.

13. Saito Y, Komohara Y, Niino D, Horlad H, Ohnishi K, Takeya H, Kawaguchi H, Shimizu H, Ohshima K, Takeya M.
Role of CD204-positive tumor associated macrophages in adult T-cell leukemia/lymphoma.
J Clin Exp Hematop 54: 59-65, 2014.

14. Furusato A, Kato H, Nehira T, Eguchi K, Kawabata T, Fujiwara Y, Losung F, Mangindaan RE, de Voogd NJ, Takeya M, Yokosawa H, Tsukamoto S.
Acanthomanzamines A-E with New Manzamine Frameworks from the Marine Sponge Acanthostrongylophora ingens.
Org Lett 16: 3888-3891, 2014.

15. Ono M, Yasuda S, Komatsu H, Fujiwara Y, Takeya M, Nohara T.
Triterpenoids from the fruits and leaves of the blackberry (Rubus allegheniensis) and their inhibitory activities on foam cell formation in human monocyte-derived macrophage.
Nat Prod Res 28: 2347-2350, 2014.

16. Kobayashi D, Hirayama M, Komohara Y, Mizuguchi S, Wilson Morifuji M, Ihn H, Takeya M, Kuramochi A, Araki N.
Translationally Controlled Tumor Protein is a Novel Biological Target for Neurofibromatosis Type 1 (NF1)-associated Tumors.
J Biol Chem 289: 26314-26326, 2014.

17. Nagai R, Shirakawa J, Fujiwara Y, Ohno R, Moroishi N, Sakata N, Nagai M.
Detection of AGEs as markers for carbohydrate metabolism and protein denaturation.
J Clin Biochem Nutr 55: 1-6, 2014.

18. Yamashita S, Sakashita N, Yamashita T, Tawara N, Tasaki M, Kawakami K, Komohara Y, Fujiwara Y, Kamikawa M, Nakagawa T, Hirano T, Maeda Y, Hasegawa M, Takeya M, Ando Y.
Concomitant accumulation of α-synuclein and TDP-43 in a patient with corticobasal degeneration.
J Neurol 261, 2209-2217, 2014.

19. Kamikawa M, Lei X, Fujiwara Y, Nishitsuji K, Mizuta H, Takeya M, Sakashita N.
ACAT1-associated Late Endosomes/Lysosomes Significantly Improve Impaired Intracellular Cholesterol Metabolism and the Survival of Niemann-Pick Type C Mice.
Acta Histochem Cytochem 47: 35-43, 2014.

20. Nohara T, Fujiwara Y, Kudo R, Yamaguchi K, Ikeda T, Murakami K, Ono M, Kajimoto T, Takeya M.
Isolation and Characterization of New Onionins A2 and A3 from Allium cepa, and of Onionins A1, A2, and A3 from Allium fistulosum.
Chem Pharm Bull (Tokyo) 62: 1141-1145, 2014.

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