氏名：粟井（塚本）博丈　　あわい（つかもと）ひろたけ
所属：熊本大学大学院生命科学研究部　先端生命医療科学部門　感染・免疫学講座　免疫識別学分野
職名：助教
専門分野：免疫生物学
所属学会：日本免疫学会
受賞：財団法人　上原記念財団　海外留学フェローシップ

発表論文
Tsukamoto, H., Clise-Dwyer, K., Huston, G. E., Duso, D. K., Buck, A. L., Haynes, L. and Swain, S. L. Age-associated increase in lifespan of naive CD4 T cells contributes to T cell homeostasis but facilitates development of functional defects. Proc. Natl. Acad. Sci. USA, 106: 18333-18338, 2009.

塚本博丈, 西村泰治：炎症・免疫分野とノーベル賞, 炎症と免疫（ 先端医学社）印刷中

Tsukamoto, H., Irie, A., Senju, S., Hatzopoulos, A. K., Wojnowski, L., and Nishimura, Y. B-Raf-mediated signaling pathway regulates T cell development. Eur. J. Immunol. 38: 518-527, 2008.

Irie, A., Harada, K., Tsukamoto, H., Kim, J-R., Araki. N., and Nishimura, Y. Protein kinase D2 contributes to either IL-2 promoter regulation or induction of cell death upon TCR stimulation depending on its activity in Jurkat cells. Int. Immunol. 18: 1737-1747, 2006.

塚本博丈, 西村泰治：抗原認識のメカニズム, Medicina,（医学書院）43 (6), 2006.

Tsukamoto, H., Irie, A., kim, J-R., Chen, Y-Z., Takeshita, K., and Nishimura, Y. TCR ligand avidity determines the mode of B-Raf/Raf-1/ERK activation leading to the activation of human CD4+ T cell clone. Eur. J. Immunol. 36: 1926-1937, 2006.

Kim, J-R., Irie, A., Tsukamoto, H., and Nishimura, Y. A role of kinase inactive ZAP-70 in altered peptide ligand stimulated T cell activation. Biochem. Biophys. Res. Comm. 341: 19-27, 2006.

Hosaka, S., Nakatsura, T., Tsukamoto, H., Hatayama, T., Baba, H., and Nishimura, Y. Synthetic small interfering RNA targeting heat shock protein 105 induces apoptosis of various cancer cells both in vitro and in vivo. Cancer Sci. 97: 623-632, 2006.

塚本博丈, 西村泰治：CLIP置換型インバリアント鎖遺伝子を利用したペプチド/MHC-II複合体発現細胞システムの構築, Medical Science Digest（ニュ−サイエンス社）31 (5): 5-6, 2005.

塚本博丈, 西村泰治：MHCによる抗原提示, バイオ研究マスターシリーズ 免疫学集中マスタ−（羊土社）84-92, 2005.

Yoshitake, Y., Nakatsura, T., Monji, M., Senju, S., Matsuyoshi, H., Tsukamoto, H., Hosaka, S., Komori, H., Fukuma, D., Ikuta, Y., Katagiri, T., Furukawa, Y., Ito, H., Shinohara, M., Nakamura, Y. and Nishimura, Y. Proliferation potential-related protein, an ideal esophageal cancer antigen for immnotherapy, identified using cDNA microarray analysis. Clinical Cancer Research 10: 6437-6448, 2004.

Tsukamoto, H., Irie, A., and Nishimura, Y. B-Raf contributes to sustained extracellular signal-regulated kinase activation that regulates IL-2 production through the T cell receptor. J. Biol. Chem. 279: 48457-48465, 2004.

Nishimura, Y., Chen, Y-Z., Uemura, Y., Tanaka,Y., Tsukamoto, H., kanai, T., Yokomizo, H., Yun, C., Matsuoka, T., Irie, A. and Matsushita, S. Degenerate recognition and response of human CD4⁺ Th cell clones: implications for basic and applied immunology. Mol. Immunol. 40: 1089-1094, 2004.

Irie, A., Chen, Y-Z., Tsukamoto, H., Jotsuka, T., Masuda, M., and Nishimura, Y. Unique T-cell proliferation associated with PKCμ activation and impaired Zap-70 phosphorylation in recognition of overexpressed HLA-DR/partially agonistic peptide complexes. Eur. J. Immunol. 33: 1497-1507, 2003.

Uemura, Y., Senju, S., Maenaka, K., Iwai, L.K., Fujii, S., Tabata, H., Tsukamoto, H., Hirata, S., Chen, Y-Z. and Nishimura, Y. Systematic analysis of the combinatorial nature of epitopes recognized by TCR leads to identification of mimicry epitopes for GAD65 specific TCRs. J. Immunol. 170: 947-960, 2003.

Yamane, T., Kunisada, T., Tsukamoto, H., Yamazaki, H., Niwa H., Takada, S. and Hayashi, S. Wnt signaling regulates hemopoiesis through stromal cells. J. lmmunol. 167: 765-772, 2001.