I. 略歴
II. 専門分野、所属学会、受賞など
III. 発表論文

I. 略歴

氏名：入江　厚（いりえ　あつし）
生年月日：1962 年（昭和37年）5月5日
所属：熊本大学大学院生命科学研究部　先端生命医療科学部門　感染・免疫学講座　免疫識別学分野　職：講師
住所：〒860-8556　熊本市本荘1丁目-1-1
TEL：096-373-5313
FAX：096-373-5314

II. 専門分野、所属学会、受賞など

専門分野：免疫生物化学　T細胞活性化分子の探索、質量分析法による免疫細胞のブロテオーム解析

所属学会：日本免疫学会

III. 発表論文

1. Fukunaga T, Soejima H, Irie A, Sugamura K, Oe Y, Tanaka T, Kojima S, Sakamoto T, Yoshimura M, Nishimura Y, Ogawa H. Expression of interferon-g and interleukin-4 production in CD4(+) T cells in patients with chronic heart failure.
   Heart Vessels. 22: 178-83, 2007.
2. Irie, A., Harada, K., Tsukamoto, H., Kim, J-R., Araki, N., and Nishimura, Y. Protein kinase D2 contributes to either IL-2 promoter regulation or induction of cell death upon TCR-stimulation depending on its activity in Jurkat cells.
   Int. Immunol. 18: 1737-1747, 2006.
3. Tsukamoto, H., Irie, A., kim, J-R., Chen, Y-Z., Takeshita, K., and Nishimura, Y.: TCR ligand avidity determines the mode of B-Raf/Raf-1/ERK activation leading to the activation of human CD4+ T cell clone.
   Eur. J. Immunol. 36: 1926-1937, 2006.
4. Kim, J-R., Irie, A., Tsukamoto, H., and Nishimura, Y. A role of kinase inactive ZAP-70 in altered peptide ligand stimulated T cell activation.
   Biochem. Biophys. Res. Comm. (IF=3.0) 341: 19-27, 2006.
5. Soejima H, Irie A, Fukunaga T, Sugamura K, Kojima S, Sakamoto T, Yoshimura M, Kishikawa H, Nishimura Y, Ogawa H.: Elevated plasma osteopontin levels were associated with osteopontin expression of CD4(+) T cells in patients with unstable angina.
   Circ. J. 70: 851-856, 2006.
6. A, Irie, Y-Z, Chen, H, Tsukamoto, T, Jotsuka, M, Masuda, and Y, Nishimura. Unique T-cell proliferation associated with PKCμ activation and impaired Zap-70 phosphorylation in recognition of overexpressed HLA-DR/partially agonistic peptide complexes.
   Eur. J. Immunol. 33: 1497-1507, 2003
7. H, Soejima, A, Irie, S, Miyamoto, I, Kajiwara, S, Kojima, J, Hokamaki, T, Sakamoto, T, Tanaka, M, Yoshimura, Y, Nishimura, and H, Ogawa. The preference to a Th1-type response in patients with coronary spastic angina.
   Circulation 170: 2196-2200, 2003
8. T. Kamata, K.K. Tieu, A, Irie, T.A. Springer, & Y. Takada 　Amino acid residues in the aIIb subunit that are critical for ligand binding to integrin aIIbb3 are clustered in the b-propeller model 　
   J. Biol. Chem. 276: 44275-44283, 2001
9. M. Minohara, H. Ochi, S. Matsushita, A. Irie, Y. Nishimura & J. Kira　Differences between T cell reactivities to major myelin protein-derived peptides in opticospinal and conventional forms of multiple sclerosis and healthy controls.　
   Tissue Antigens 57: 447-456, 2001
10. J.M.G. Higgins, M. Cernadas, K. Tan, A. Irie, J. Wang, Y. Takada & M.B. Brenner 　The role of a and b chains in ligand recognition by b7 Integrins.　　
    J. Biol. Chem. 275: 25652-25664, 2000
11. 入江　厚、他１名　抗原提示細胞とＴ細胞のインターフェースにおける抗原認識の分子機構　
    臨床免疫　34: 197-203, 2000
12. 入江　厚、他１名　免疫遺伝学と遺伝病　
    病理と臨床　18: 841-852, 2000
13. 入江　厚、他１名　抗原提示細胞とＴ細胞のインターフェースにおける抗原認識の分子機構　
    Annual Review 免疫 2001（矢田、奥村、佐藤　編）　中外医学社、p84-93, 2000（分担）
14. C. Yun, S. Senju, H. Fujita, Y. Tsuji, A. Irie, S. Matsushita & Y. Nishimura　Augmentation of immune response by altered peptide ligands of the antigenic peptide in a human CD4+ T-cell clone reacting to TEL/AML1 fusion protein.　
    Tissue Antigens 54: 153-161, 1999
15. X.P. Zhang, W. Puzon-McLaughlin, A. Irie, N. Kovach, N.L. Prokopishyn, S. Laferte, K. Takeuchi, T. Tsuji & Y. Takada.　a3b1 adhesion to laminin-5 and invasin: critical and differential role of integrin residues clustered at the boundary between a3 N-terminal repeats 2 and 3.　
    Biochemistry 38: 14424-14431, 1999
16. 入江　厚、他１名　Ｔ細胞とＭＨＣの相互作用　免疫　しくみと疾患のすべて　（宮坂信之　編）　羊土社、p30-43, 1998（分担）
17. A. Irie, T. Kamata & Y. Takada.　Multiple loop structures critical for ligand binding of the integrin a4 subunit in the upper face of the b-propeller model.　
    Proc. Natl. Acad. Sci. U.S.A. 94 : 7198-7203 1997
18. A.P. Mould, J.A. Askari, S. Aota, K.M. Yamada, A. Irie, Y. Takada, H.J. Mardon & M.J. Humphries.　Defining the topology of integrin a5b1-fibronectin interactions using inhibitory anti-a5 and anti-b1 monoclonal antibodies. Evidence that the synergy sequence of fibronectin is recognized by the amino-terminal repeats of the a5 subunit.　
    J. Biol. Chem. 272 : 17283-17292 1997
19. Y. Takada, T. Kamata, A. Irie, W. Puzon-McLaughlin & X.P. Zhang.　Structural basis of integrin-mediated signal transduction.　
    Matrix Biol. 16 : 143-151 1997
20. 入江　厚、他２名　インテグリンとリガンドの結合機構　
    蛋白質核酸酵素　42: 1679-1686, 1997
21. N. Matsuura, W. Puzon-McLaughlin, A. Irie, Y. Morikawa, K. Kakudo & Y. Takada　Induction of experimental bone metastasis in mice by transfection of integrin a4b1 into tumor cells.　
    Am. J. Pathol. 148 : 55-61, 1996
22. H. Yamamoto, A. Irie, Y. Fukushima, T. Ohnishi, N. Arita, T. Hayakawa & K. Sekiguchi　Abrogation of lung metastasis of human fibrosarcoma cells by ribozyme-mediated suppression of integrin a6 subunit expression.　
    Int. J. Cancer 65: 519-524, 1996
23. T. Kamata, A. Irie, M. Tokuhira & Y. Takada　Critical residues of integrin aIIb subunit for binding of aIIbb3 (glycoprotein IIb-IIIa) to fibrinogen and ligand-mimetic antibodies (PAC-1, OP-G2, and LJ-CP3).　
    J. Biol. Chem. 271: 18610-18615, 1996
24. 入江　厚、他２名　インテグリンファミリー　
    臨床病理　102: 16-23, 1996
25. 入江　厚、他０名　インテグリンの多様性とリガンド認識機構 　
    組織培養　22: 530-534, 1996
26. 高田義一、鎌田徹治、入江　厚、他１名　インテグリンの構造と機能 　
    実験医学　14 : 2317-2322, 1996
27. M. Ogiso, M. Ohta, A. Irie, M. Hoshi & M. Komoto　Characterization of neutral glycosphingolipids in rat lens.
    Exp. Eye Res. 60: 193-198, 1995
28. A. Irie, T. Kamata, W. Puzon-McLaughlin & Y. Takada　Critical amino acid residues for ligand binding are clustered in a predicted b-turn of the third N-terminal repeat in the integrin a4 and a5 subunits.　
    EMBO J. 14: 5550-5556, 1995
29. M. Ogiso, A. Irie, H. Kubo, M. Komoto, T. Matsuno, Y. Koide & M. Hoshi　Characterization of neutral glycosphingolipids in human cataractous lens.　
    J. Biol. Chem. 268: 13242-13247, 1993
30. 入江　厚、他１名　インテグリンファミリー 　
    メビオ　10: 18-25, 1993
31. M. Ogiso, A. Irie, H. Kubo, M. Hoshi & M. Komoto　Senile cataract-related accumulation of Lewis(x) glycolipid in human lens.　
    J. Biol. Chem. 267: 6467-6470, 1992
32. H. Kubo, G.J. Jiang, A. Irie, M. Morita, T. Matsubara & M. Hoshi　A novel ceramide trihexoside from the eggs of the sea urchin, Hemicentrotus pulcherrimus.　
    J. Biochem. 111: 726-731, 1992
33. H. Kubo, G.J. Jiang, A. Irie, M. Suzuki, F. Inagaki & M. Hoshi　A novel difucosylated neutral glycosphingolipid from the eggs of the sea urchin, Hemicentrotus pulcherrimus: I. Purification and structural determination of the glycolipid.　
    J. Biochem. 112: 281-285, 1992
34. 関口清俊、入江　厚、他０名　WI-38 　
    生体の科学　43 : 432　1992
35. A. Irie, H. Kubo & M. Hoshi. Glucosylceramide having a novel tri-unsaturated long-chain base from the spermatozoa of the starfish, Asterias amurensis.　
    J. Biochem. 107: 578-586, 1990
36. H. Kubo, A. Irie, F. Inagaki & M. Hoshi　Gangliosides from the eggs of the sea urchin, Anthocidaris crassispina.　
    J. Biochem. 108: 185-192, 1990
37. A. Irie, H. Kubo, F. Inagaki & M. Hoshi　Ceramide dihexosides from the spermatozoa of the starfish, Asterias amurensis, consist of gentiobiosyl- cellobiosyl-, and lactosylceramide.　
    J. Biochem. 108: 531-536, 1990
38. H. Kubo, A. Irie, F. Inagaki & M. Hoshi　Melibiosylceramide as the sole ceramide dihexoside from the eggs of the sea urchin, Anthocidaris crassispina.　
    J. Biochem. 104: 755-760, 1988